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    IMMUNE REPERTOIRE MONITORING
    1.
    发明申请
    IMMUNE REPERTOIRE MONITORING 有权

    公开(公告)号：US20210108268A1

    公开(公告)日：2021-04-15

    申请号：US15733628

    申请日：2019-03-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Timothy LOONEY

    IPC: C12Q1/6886

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, methods provide for determining convergence of T cell receptor and/or B cell receptor repertoires in samples prior to a treatment and predicting a subjects response to the treatment based on the measured convergence frequency. In another aspect, methods provide for an immune receptor haplotype group and predicting a subjects potential or predisposition to be protected from or vulnerable to an adverse event following a treatment.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 有权

    公开(公告)号：US20220073983A1

    公开(公告)日：2022-03-10

    申请号：US17250406

    申请日：2019-07-18

    Applicant: Life Technologies Corporation

    Inventor： Timothy LOONEY ,  Chenchen YANG ,  Geoffrey LOWMAN

    IPC: C12Q1/6881 ,  C12N15/10

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of nucleic acid sequences of murine T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 审中-公开

    公开(公告)号：US20180208984A1

    公开(公告)日：2018-07-26

    申请号：US15873862

    申请日：2018-01-17

    Applicant: Life Technologies Corporation

    Inventor： Timothy LOONEY ,  Geoffrey LOWMAN ,  Lifeng LIN

    IPC: C12Q1/6876 ,  C12Q1/6869 ,  C12Q1/6844 ,  C12Q1/6811

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 有权

    公开(公告)号：US20220002802A1

    公开(公告)日：2022-01-06

    申请号：US17250408

    申请日：2019-07-18

    Applicant: Life Technologies Corporation

    Inventor： Timothy LOONEY ,  Geoffrey LOWMAN ,  Lifeng LIN ,  Chenchen YANG

    IPC: C12Q1/6881 ,  C12N15/10

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

    METHODS FOR CONTEXT BASED COMPRESSION OF GENOMIC DATA FOR IMMUNO-ONCOLOGY BIOMARKERS
    8.
    发明申请
    METHODS FOR CONTEXT BASED COMPRESSION OF GENOMIC DATA FOR IMMUNO-ONCOLOGY BIOMARKERS 审中-公开

    公开(公告)号：US20200335176A1

    公开(公告)日：2020-10-22

    申请号：US16851472

    申请日：2020-04-17

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Fiona Hyland ,  Asha KAMAT ,  Timothy LOONEY

    IPC: G16B20/20 ,  G06N3/12 ,  G06F16/2457 ,  G06F16/248

    Abstract: The method includes compressing numbers of reads data for targeted genes of a gene expression assay performed on a test sample. The targeted genes are organized into categories. Each category represents a functional context associated with the targeted genes in that category. The numbers of reads corresponding to targeted genes each category is compressed to form a compressed value for the category. The compressed value is compared to a baseline value for the category to determine an enrichment or a loss of a signature corresponding to the functional context of the category. The method may include analyzing information from multiple assays performed on the test sample, assigning a score value to each assay result and predicting a response to immune-oncology treatment based on the assigned scores.

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