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公开(公告)号：US11021453B2
公开(公告)日：2021-06-01
申请号：US16717813
申请日：2019-12-17
发明人： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC分类号： C07D295/205 , A61P25/22 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
摘要： This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号：US10463753B2
公开(公告)日：2019-11-05
申请号：US15999117
申请日：2017-02-17
摘要： Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.
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公开(公告)号：US10450302B2
公开(公告)日：2019-10-22
申请号：US15573272
申请日：2016-05-10
发明人： Jacqueline Lorayne Blankman , Jason Robert Clapper , R. Alan B. Ezekowitz , Iain Peter Fraser , Cheryl A. Grice , Todd K. Jones , Gary Paul O'Neill , Archie Wayne Thurston, Jr. , Channing Rodney Beals
IPC分类号： A61K31/495 , A61P29/00 , A61P25/00 , C07D295/205 , C07D403/10
摘要： Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
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公开(公告)号：US10781211B2
公开(公告)日：2020-09-22
申请号：US16300501
申请日：2017-05-11
发明人： Daniel J. Buzard , Michael B. Shaghafi , Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Olivia D. Weber
IPC分类号： C07D471/10 , C07D519/00 , A61K31/499 , A61K31/5377 , A61K31/55 , A61P25/28 , A61P29/00 , A61P25/08 , A61K31/538 , A61K31/541
摘要： Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US10519134B2
公开(公告)日：2019-12-31
申请号：US15777198
申请日：2016-11-18
IPC分类号： C07D401/14 , C07D413/14 , C07D487/10 , C07D497/08 , A61P25/04 , C07D491/08
摘要： Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US10385057B2
公开(公告)日：2019-08-20
申请号：US15777199
申请日：2016-11-18
发明人： Cheryl A. Grice , Todd K. Jones , Katharine K. Duncan , Olivia D. Weber , Justin S. Cisar , Jeffrey E. Merit
IPC分类号： C07D487/04 , C07D487/10 , C07D403/06 , C07D519/00 , C07D401/14 , C07D403/14 , C07D417/14
摘要： Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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