公开(公告)号：US20150328307A1

公开(公告)日：2015-11-19

申请号：US14716481

申请日：2015-05-19

Applicant: MERIAL, INC.

Inventor： Paulraj Lawrence ,  Russell Bey

IPC: A61K39/225 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61K39/225 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/14041 ,  C12N2770/20034

Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.

Abstract translation: 本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。 疫苗或组合物可以是含有PEDV抗原的疫苗或组合物。 本发明还包括编码和表达可用于保护猪动物抵抗PEDV的PEDV抗原，表位或免疫原的重组载体。

公开(公告)号：US10098941B2

公开(公告)日：2018-10-16

申请号：US15419568

申请日：2017-01-30

Applicant: MERIAL, INC.

Inventor： Tammy (Kolander) Bremer ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/102 ,  A61K39/00 ,  A61K45/06 ,  C12N1/38 ,  C12N1/36

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

公开(公告)号：US20170157232A1

公开(公告)日：2017-06-08

申请号：US15419568

申请日：2017-01-30

Applicant: MERIAL, INC.

Inventor： Tammy (Kolander) Bremer ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/02

CPC classification number: A61K39/102 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C12N1/36 ,  C12N1/38

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

公开(公告)号：US20150273045A1

公开(公告)日：2015-10-01

申请号：US14668656

申请日：2015-03-25

Applicant: MERIAL, INC.

Inventor： Tammy Kolander ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/102 ,  C12N1/36 ,  C12N1/38 ,  A61K45/06

CPC classification number: A61K39/102 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C12N1/36 ,  C12N1/38

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

Abstract translation: 本公开提供减毒的嗜热索氏杆菌菌株，包含其的组合物，及其生产和使用方法。 相对于相应的致病菌，减毒菌株可以表达较低或没有各种毒力相关基因的水平。有利的是，减毒的Histophilus somni菌株可以口服，鼻内，气管内或皮下给药。

公开(公告)号：US09713639B2

公开(公告)日：2017-07-25

申请号：US14716481

申请日：2015-05-19

Applicant: MERIAL, INC.

Inventor： Paulraj Lawrence ,  Russell Bey

IPC: A61K39/215 ,  A61K39/295 ,  A61K39/12 ,  A61K39/225 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/215 ,  A61K39/225 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/14041 ,  C12N2770/20034

Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.

公开(公告)号：US09592283B2

公开(公告)日：2017-03-14

申请号：US14668656

申请日：2015-03-25

Applicant: MERIAL, INC.

Inventor： Tammy Kolander ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/102 ,  A61K45/06 ,  C12N1/36 ,  C12N1/38 ,  A61K39/00

CPC classification number: A61K39/102 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C12N1/36 ,  C12N1/38

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

Abstract translation: 本公开提供减毒的嗜热索氏杆菌菌株，包含其的组合物，及其生产和使用方法。 相对于相应的致病菌，减毒菌株可以表达较低或没有各种毒力相关基因的水平。有利的是，减毒的Histophilus somni菌株可以口服，鼻内，气管内或皮下给药。