公开(公告)号：US20190133129A1

公开(公告)日：2019-05-09

申请号：US16182838

申请日：2018-11-07

Applicant: MERIAL INC.

Inventor： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: A01N43/80 ,  C07D261/04 ,  A01N43/42 ,  A61K31/42 ,  C07D453/04

Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US20180354917A1

公开(公告)日：2018-12-13

申请号：US15946642

申请日：2018-04-05

Applicant: MERIAL INC.

Inventor： Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: C07D261/04

Abstract: The present invention provides crystalline forms of compound of formula (Ia) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and methods of use of the crystalline forms.

公开(公告)号：US20170311601A1

公开(公告)日：2017-11-02

申请号：US15480316

申请日：2017-04-05

Applicant: MERIAL INC.

Inventor： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: A01N43/80 ,  A01N43/42 ,  A61K31/42 ,  C07D261/04

CPC classification number: A01N43/80 ,  A01N43/42 ,  A61K31/42 ,  C07D261/04 ,  C07D453/04

Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US10433552B2

公开(公告)日：2019-10-08

申请号：US15480316

申请日：2017-04-05

Applicant: MERIAL INC.

Inventor： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: C07D453/04 ,  A01N43/80 ,  C07D261/04 ,  A01N43/42 ,  A61K31/42

Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.