公开(公告)号：US20190133129A1

公开(公告)日：2019-05-09

申请号：US16182838

申请日：2018-11-07

申请人： MERIAL INC.

发明人： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC分类号： A01N43/80 ,  C07D261/04 ,  A01N43/42 ,  A61K31/42 ,  C07D453/04

摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US10433552B2

公开(公告)日：2019-10-08

申请号：US15480316

申请日：2017-04-05

申请人： MERIAL INC.

发明人： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC分类号： C07D453/04 ,  A01N43/80 ,  C07D261/04 ,  A01N43/42 ,  A61K31/42

摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US20170311601A1

公开(公告)日：2017-11-02

申请号：US15480316

申请日：2017-04-05

申请人： MERIAL INC.

发明人： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC分类号： A01N43/80 ,  A01N43/42 ,  A61K31/42 ,  C07D261/04

CPC分类号： A01N43/80 ,  A01N43/42 ,  A61K31/42 ,  C07D261/04 ,  C07D453/04

摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.