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公开(公告)号：US20190133129A1
公开(公告)日：2019-05-09
申请号：US16182838
申请日：2018-11-07
申请人： MERIAL INC.
发明人： Chunhua Yang , Loic Patrick Le Hir de Fallois , Charles Q. Meng , Alan Long , Roelof Johannes Gorter de Vries , Bruno Baillon , Sylvaine Lafont , Myriam Gay de Saint Michel , Stephane Kozlovic
IPC分类号： A01N43/80 , C07D261/04 , A01N43/42 , A61K31/42 , C07D453/04
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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2.发明申请公开(公告)号：US20160251317A1
公开(公告)日：2016-09-01
申请号：US15148168
申请日：2016-05-06
申请人： MERIAL INC.
发明人： Charles Q. Meng
IPC分类号： C07D235/28 , A61K45/06 , A61K31/277 , A61K31/4184
CPC分类号： C07D235/28 , A61K31/277 , A61K31/4184 , A61K45/06 , C07D235/08 , C07D235/10 , C07D235/18 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10
摘要： The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
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公开(公告)号：US20160185726A1
公开(公告)日：2016-06-30
申请号：US14981847
申请日：2015-12-28
申请人： MERIAL, INC.
发明人： Charles Q. Meng , Alan Long , Scot Huber , Srinivas Reddy Gurrala , Douglas Edward Wilkinson , Gregory Pacofsky
IPC分类号： C07D215/38 , A61K31/495 , A61K31/496 , C07D307/81 , C07C233/56 , A61K31/167 , C07D401/12 , C07D263/58 , C07D211/58 , C07D277/64 , C07D277/82 , C07D471/08 , C07D213/74 , C07D333/66 , C07D333/60 , A61K31/47 , A61K31/4995 , A61K31/472 , C07D295/16
CPC分类号： C07D215/38 , A61K31/167 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07C233/56 , C07C235/16 , C07C2601/14 , C07D211/58 , C07D213/74 , C07D215/42 , C07D217/06 , C07D241/04 , C07D263/58 , C07D277/64 , C07D277/82 , C07D295/15 , C07D295/16 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/81 , C07D307/82 , C07D333/60 , C07D333/66 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/08 , Y02A50/423
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
摘要翻译： 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。
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公开(公告)号：US09249102B2
公开(公告)日：2016-02-02
申请号：US14083879
申请日：2013-11-19
申请人： MERIAL INC.
IPC分类号： A61K31/497 , C07D401/00 , C07D215/38 , A61K31/167 , A61K31/4704 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07D241/04 , C07D277/64 , C07D307/81 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/08 , C07D403/12 , C07D213/74 , C07D215/42 , C07D217/06 , C07D333/66 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D263/58 , C07D277/82 , C07D295/15 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/82 , C07C233/56 , C07C235/16
CPC分类号： C07D215/38 , A61K31/167 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07C233/56 , C07C235/16 , C07C2601/14 , C07D211/58 , C07D213/74 , C07D215/42 , C07D217/06 , C07D241/04 , C07D263/58 , C07D277/64 , C07D277/82 , C07D295/15 , C07D295/16 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/81 , C07D307/82 , C07D333/60 , C07D333/66 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/08
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
摘要翻译： 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。
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公开(公告)号：US20170311601A1
公开(公告)日：2017-11-02
申请号：US15480316
申请日：2017-04-05
申请人： MERIAL INC.
发明人： Chunhua Yang , Loic Patrick Le Hir de Fallois , Charles Q. Meng , Alan Long , Roelof Johannes Gorter de Vries , Bruno Baillon , Sylvaine Lafont , Myriam Gay de Saint Michel , Stephane Kozlovic
IPC分类号： A01N43/80 , A01N43/42 , A61K31/42 , C07D261/04
CPC分类号： A01N43/80 , A01N43/42 , A61K31/42 , C07D261/04 , C07D453/04
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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公开(公告)号：US10433552B2
公开(公告)日：2019-10-08
申请号：US15480316
申请日：2017-04-05
申请人： MERIAL INC.
发明人： Chunhua Yang , Loic Patrick Le Hir de Fallois , Charles Q. Meng , Alan Long , Roelof Johannes Gorter de Vries , Bruno Baillon , Sylvaine Lafont , Myriam Gay de Saint Michel , Stephane Kozlovic
IPC分类号： C07D453/04 , A01N43/80 , C07D261/04 , A01N43/42 , A61K31/42
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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公开(公告)号：US10155725B2
公开(公告)日：2018-12-18
申请号：US14981847
申请日：2015-12-28
申请人： MERIAL, INC.
发明人： Charles Q. Meng , Alan Long , Scot Huber , Srinivas Reddy Gurrala , Douglas Edward Wilkinson , Gregory Pacofsky
IPC分类号： A61K31/497 , C07D215/38 , A61K31/167 , A61K31/4704 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07D241/04 , C07D277/64 , C07D307/81 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/08 , C07D403/12 , C07D213/74 , C07D215/42 , C07D217/06 , C07D333/66 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D263/58 , C07D277/82 , C07D295/15 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/82 , C07C233/56 , C07C235/16 , A61K31/47 , A61K31/472 , C07D211/58 , C07D295/16 , C07D333/60
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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8.发明申请公开(公告)号：US20170239218A1
公开(公告)日：2017-08-24
申请号：US15441297
申请日：2017-02-24
申请人： MERIAL INC.
发明人： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC分类号： A61K31/415 , A61K9/00 , A61K47/10 , A01N43/80
CPC分类号： A61K31/415 , A01N43/80 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/107 , A61K31/42 , A61K31/422 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A01N25/02 , A01N25/22
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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公开(公告)号：US20170233438A1
公开(公告)日：2017-08-17
申请号：US15378219
申请日：2016-12-14
申请人： MERIAL INC.
CPC分类号： C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , C07D273/00 , C07D413/14
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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