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公开(公告)号：US10392341B2
公开(公告)日：2019-08-27
申请号：US16148822
申请日：2018-10-01
Applicant: ModernaTX, Inc.
Inventor： Kerry E. Benenato , Mark Cornebise
IPC: A61K9/51 , A61K9/00 , A61K48/00 , C12N15/63 , C07C229/12 , A61K9/127 , C07C271/20 , C07C279/12 , C07C279/28 , C07C279/32 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D207/27 , C07D277/38 , C07C275/14 , C07C279/24 , C07C311/05 , C07C229/16 , C07C335/08 , C07C233/36 , C07C235/10 , C07C255/24 , C07F9/09 , A61K9/16 , A61K38/18 , C07K14/505 , A61K47/54 , A61K47/69 , C07C227/16 , A61K31/7105 , A61K38/17 , C07C227/18
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US20170210698A1
公开(公告)日：2017-07-27
申请号：US15476263
申请日：2017-03-31
Applicant: MODERNATX, Inc.
IPC: C07C229/12 , A61K38/18 , A61K9/00 , A61K9/16
CPC classification number: C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US12077501B2
公开(公告)日：2024-09-03
申请号：US16620666
申请日：2018-06-14
Applicant: ModernaTX, Inc.
Inventor： Kerry E. Benenato , William Butcher
IPC: A61K9/51 , A61K47/60 , C07D207/09 , C07D211/28 , A61K31/7105 , A61K45/06
CPC classification number: C07D211/28 , A61K9/51 , A61K47/60 , C07D207/09 , A61K31/7105 , A61K45/06
Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US10799463B2
公开(公告)日：2020-10-13
申请号：US16065067
申请日：2016-12-22
Applicant: ModernaTX, Inc.
Inventor： Kerry E. Benenato , William Butcher
IPC: A61K9/51 , C07D295/185 , C07D211/16 , C07D295/13 , C07D211/14 , A61K38/18 , A61K47/22 , A61K48/00 , C07D241/04 , A61K9/127 , B82Y5/00
Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US10266485B2
公开(公告)日：2019-04-23
申请号：US16005286
申请日：2018-06-11
Applicant: ModernaTX, Inc.
Inventor： Kerry E. Benenato
IPC: A61K48/00 , A61K9/127 , C07C229/12 , C07C271/20 , C07C279/12 , C07C279/28 , C07C279/32 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D207/27 , C07D277/38 , C07C275/14 , C07C279/24 , C07C311/05 , C07C229/16 , C07C335/08 , C07C233/36 , C07C235/10 , C07C255/24 , C07F9/09 , A61K9/16 , A61K38/18 , C07K14/505 , A61K9/00 , A61K47/54 , A61K47/69 , C07C227/16 , A61K9/51 , A61K31/7105 , A61K38/17 , C07C227/18
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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Patent Agency Ranking
公开(公告)号：US09867888B2
公开(公告)日：2018-01-16
申请号：US15493281
申请日：2017-04-21
Applicant: MODERNATX, Inc.
Inventor： Kerry E. Benenato
IPC: A61K48/00 , A61K9/51 , A61K31/7105 , C07C229/16 , C07C227/18 , A61K38/17 , A61K38/18
CPC classification number: C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US20180273467A1
公开(公告)日：2018-09-27
申请号：US16005286
申请日：2018-06-11
Applicant: ModernaTX, Inc.
Inventor： Kerry E. Benenato
IPC: C07C229/12 , A61K9/127 , C07C335/08 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/09 , C07K14/505 , A61K9/00 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , A61K9/16 , A61K38/18 , A61K47/54 , A61K47/69 , A61K48/00 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C311/05
CPC classification number: A61K48/0033 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/12 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US09868693B2
公开(公告)日：2018-01-16
申请号：US15498698
申请日：2017-04-27
Applicant: MODERNATX, Inc.
Inventor： Kerry E. Benenato
IPC: A61K48/00 , A61K31/7105 , A61K9/51 , C07C229/12 , A61K9/16 , C07C227/16 , A61K38/18
CPC classification number: C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US20170233332A1
公开(公告)日：2017-08-17
申请号：US15498698
申请日：2017-04-27
Applicant: MODERNATX, Inc.
IPC: C07C229/12 , C07C227/16 , A61K38/18 , A61K9/16
CPC classification number: C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US20170224844A1
公开(公告)日：2017-08-10
申请号：US15493281
申请日：2017-04-21
Applicant: MODERNATX, Inc.
IPC: A61K48/00 , C07C227/18 , A61K38/18 , A61K31/7105 , A61K38/17 , C07C229/16 , A61K9/51
CPC classification number: C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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