公开(公告)号：US10208014B2

公开(公告)日：2019-02-19

申请号：US14533114

申请日：2014-11-05

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D339/04 ,  C07C69/587

摘要： The invention relates to valproic acid derivatives or pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of valproic acid derivatives, and methods for treating or preventing neurological disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, migraine, schizophrenia, depression, Alzheimer's disease, cancer, HIV and familial adenomatous polyposis.

公开(公告)号：US09624168B2

公开(公告)日：2017-04-18

申请号：US14399524

申请日：2013-08-17

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07C323/59 ,  C07C323/52 ,  A61K31/202 ,  A61K47/48

CPC分类号： C07C323/59 ,  A61K31/202 ,  A61K47/54 ,  C07C323/52

摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammation and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hypertriglyceridemia, steatohepatitis, cystinosis and inflammatory diseases.

公开(公告)号：US09580383B2

公开(公告)日：2017-02-28

申请号：US14533116

申请日：2014-11-05

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07C261/00 ,  C07C271/22

CPC分类号： C07C271/22 ,  C07C271/00 ,  C07C271/16 ,  C07D339/04

摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing multiple sclerosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurodegenerative diseases and other neuro-inflammatory diseases.

摘要翻译： 本发明涉及式I和式II化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。 药物组合物包含有效量的式I或式II化合物; 并且可以配制用于治疗或预防多发性硬化的方法用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这样的组合物可用于治疗神经变性疾病和其它神经炎症性疾病。

公开(公告)号：US09403857B2

公开(公告)日：2016-08-02

申请号：US14399198

申请日：2013-02-28

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： A61K31/675 ,  C07F9/6558 ,  C07D339/04 ,  C07D409/12

CPC分类号： C07F9/65586 ,  C07D339/04 ,  C07D409/12

摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating or preventing or modulating metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. such compositions may be used to treatment of fasting hyperglycemia, diabetes mellitus type 2, impaired fasting glucose, impaired glucose tolerance, or insulin resistance, high blood pressure, central obesity (also known as visceral, male-pattern or apple-shaped adiposity), overweight with fat deposits mainly around the waist, decreased HDL cholesterol, elevated triglycerides, hyperuricemia, fatty liver (especially in concurrent obesity) progressing to NAFLD, polycystic ovarian syndrome (in women), hypophosphatemia, renal diseases, albuminuria, end stage renal disease, and acanthosis nigricans.

摘要翻译： 本发明涉及式I和式II化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I或式II化合物的药物组合物，以及用于治疗或预防或调节代谢综合征的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或 注射。 这种组合物可用于治疗空腹高血糖症，2型糖尿病，空腹血糖受损，葡萄糖耐量降低或胰岛素抵抗，高血压，中枢性肥胖（也称为内脏，雄性模式或苹果形肥胖） 脂肪沉积主要在腰围附近，HDL胆固醇降低，甘油三酯升高，高尿酸血症，脂肪肝（特别是并发肥胖）进展到NAFLD，多囊卵巢综合征（女性），低磷血症，肾脏疾病，蛋白尿，终末期肾病， 和黑棘皮病。

公开(公告)号：US20160207886A1

公开(公告)日：2016-07-21

申请号：US15083319

申请日：2016-03-29

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D211/60 ,  C07C65/11 ,  C07C53/126 ,  C07C57/12

CPC分类号： C07D211/60 ,  A61P29/00 ,  C07C53/126 ,  C07C57/03 ,  C07C57/12 ,  C07C65/11 ,  C07C237/04 ,  C07D233/06 ,  C07D233/50

摘要： The invention relates to the compounds of formula V or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula V and methods for the treatment of inflammation and pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of pain, oral mucosal inflammatory or oral infectious diseases.

摘要翻译： 本发明涉及式V化合物或其药学上可接受的多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式V化合物的药物组合物和用于治疗炎症和疼痛的方法可以配制用于口服，口腔，直肠，局部，经皮，经粘膜，锭剂，喷雾剂，静脉内，口服溶液，口腔粘膜层片剂 ，肠胃外给药，糖浆或注射剂。 这样的组合物可用于治疗疼痛，口腔粘膜炎症或口腔传染病。

公开(公告)号：US09321716B1

公开(公告)日：2016-04-26

申请号：US14533115

申请日：2014-11-05

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： A61K31/21 ,  C07C69/736 ,  A61K31/235 ,  A61K47/48 ,  C07C233/49 ,  A61K31/24

CPC分类号： A61K31/24 ,  A61K31/235 ,  C07C233/20

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout, dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物和用于治疗代谢综合征的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 此类组合物可用于治疗高尿酸血症，痛风，血脂异常，肥胖症，尿素循环障碍，高血糖症，胰岛素抵抗，糖尿病，尿崩症，1型糖尿病，2型糖尿病，微血管并发症，大血管并发症，脂质障碍，糖尿病前期， 肥胖，心律失常，心肌梗死，中风，神经病，肾并发症，高甘油三酯血症，心血管并发症和餐后高血糖症。

公开(公告)号：US09242939B2

公开(公告)日：2016-01-26

申请号：US14399202

申请日：2013-02-24

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D221/28 ,  A61K31/485 ,  C07D471/08 ,  A61K47/48

CPC分类号： C07D221/28 ,  A61K31/485 ,  A61K47/48038 ,  A61K47/48061 ,  A61K47/542 ,  A61K47/545 ,  C07D471/08

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants, upper respiratory infections, (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis, neuropathic pain and pain associated with fibromyalgia.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物和用于治疗呼吸系统疾病的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这种组合物可用于治疗由轻微喉咙和支气管刺激引起的咳嗽（例如通常伴有流感和感冒），以及由吸入性粒子刺激物引起的咳嗽症状，上呼吸道感染（假性筋感染），肌萎缩症患者 侧索硬化和多发性硬化，神经性疼痛和与纤维肌痛相关的疼痛。

公开(公告)号：US20150218136A1

公开(公告)日：2015-08-06

申请号：US14399174

申请日：2013-04-19

申请人： Mahesh KANDULA

发明人： Mahesh Kandula

IPC分类号： C07D409/12 ,  C07D333/24

CPC分类号： C07D409/12 ,  C07D333/20 ,  C07D333/24

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of neurologic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of depression, Alzheimer's disease, multiple sclerosis, Batten disease, multiple sclerosis, Parkinson's disease (PD) and restless legs syndrome (RLS).

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物的药物组合物和治疗神经疾病的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这样的组合物可用于治疗抑郁症，阿尔茨海默氏病，多发性硬化，巴特氏病，多发性硬化，帕金森病（PD）和不宁腿综合征（RLS）。

公开(公告)号：US20150133475A1

公开(公告)日：2015-05-14

申请号：US14399177

申请日：2013-05-13

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D473/04 ,  A61K47/48 ,  A61K31/42

CPC分类号： C07D473/04 ,  A61K31/194 ,  A61K31/198 ,  A61K31/202 ,  A61K31/42 ,  A61K31/425 ,  A61K31/4439 ,  A61K31/455 ,  A61K31/522 ,  A61K31/618 ,  A61K47/48038 ,  A61K47/48061 ,  A61K47/542 ,  A61K47/545 ,  A61K2300/00

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of periodontitis and rheumatoid arthritis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物和用于治疗牙周炎和类风湿性关节炎的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。

公开(公告)号：US20150119453A1

公开(公告)日：2015-04-30

申请号：US14399190

申请日：2013-02-01

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D339/04 ,  A61K47/48

CPC分类号： C07D339/04 ,  A61K47/48038 ,  A61K47/48061 ,  A61K47/542 ,  A61K47/545 ,  C07C219/08 ,  C07C2601/14 ,  C07D209/14 ,  C07D213/20 ,  C07D213/66 ,  C07D495/04

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing depression may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of major depressive disorder (MDD), anxiety, neurological diseases, general anxiety disorder, social phobia, panic disorder, vasomotor symptoms, diabetic neuropathy, epilepsy, bipolar disorder, migraine, schizophrenia, cancer, menopause, HIV and familial adenomatous polyposis.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物的药物组合物，以及用于治疗或预防抑郁症的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这些组合物可用于治疗重度抑郁障碍（MDD），焦虑症，神经疾病，一般焦虑症，社交恐惧症，惊恐障碍，血管舒缩症状，糖尿病性神经病，癫痫，双相情感障碍，偏头痛，精神分裂症，癌症，绝经期，HIV 和家族性腺瘤性息肉病。