公开(公告)号：US10011876B2

公开(公告)日：2018-07-03

申请号：US13988764

申请日：2011-06-21

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C12Q1/68 ,  C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： This disclosure generally relates to a method, a system and a kit for diagnosing and treating various disease conditions using the gene expression value in a given sample obtained from a subject. This disclosure further relates to selecting the right set of genes as a portfolio of genes for a particular disease. Providing a set of appropriate portfolio of gene for studying the gene expression values and using the values as a diagnostic tool is also disclosed. The gene expression value is further used for intervention by pharmaceuticals as a prediction model for the treatment of the disease. An individual may have a personalized health card that may store the gene expression value for that particular individual. A system may store the data for portability and integrated view of the individual's medical data for effective diagnosis and treatment.

公开(公告)号：US09988340B2

公开(公告)日：2018-06-05

申请号：US14791492

申请日：2015-07-06

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： A61K31/66 ,  C07C69/73 ,  C07D317/30 ,  C07C69/593 ,  C07C69/732 ,  C07C69/60

CPC分类号： C07C69/73 ,  C07C69/593 ,  C07C69/60 ,  C07C69/732 ,  C07D317/30

摘要： The invention relates to the compounds of formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula II; and methods for treating or preventing multiple sclerosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurodegenerative diseases and other inflammatory diseases.

公开(公告)号：US09840472B2

公开(公告)日：2017-12-12

申请号：US14816089

申请日：2015-08-03

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D233/44 ,  C07C53/126 ,  C07D307/68 ,  C07C229/28 ,  C07C229/08 ,  C07C229/46 ,  C07D233/50 ,  C07C69/60

CPC分类号： C07D233/44 ,  C07C53/126 ,  C07C69/60 ,  C07C229/08 ,  C07C229/28 ,  C07C229/46 ,  C07C2601/14 ,  C07D233/50 ,  C07D307/68

摘要： The invention relates to the compounds of formula I, formula II, formula III and formula IV or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III or formula IV and methods for the treatment of mucositis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of mucositis and oral mucosal inflammatory or oral infectious diseases.

公开(公告)号：US09573927B2

公开(公告)日：2017-02-21

申请号：US14399176

申请日：2013-02-04

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D339/04 ,  A61K9/70 ,  A61K31/135 ,  A61K31/381 ,  A61K31/385 ,  A61K31/4045 ,  A61K31/4188

CPC分类号： C07D339/04 ,  A61K9/70 ,  A61K31/135 ,  A61K31/381 ,  A61K31/385 ,  A61K31/4045 ,  A61K31/4188

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of severe pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic pain, generalized pain disorders, leukemia, cancer, chronic pain, chemotherapy induced pain, epilepsy, migraine, neuropathic pain, post herpetic neuralgia, neuralgia, pain, drug addiction, detoxification of drugs, Alzheimer's disease, multiple sclerosis, multiple sclerosis, restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, amyotrophic lateral sclerosis (ALS), convulsions, partial seizures, mood-stabilizing agent and bipolar disorder.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物的药物组合物和用于治疗严重疼痛的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这些组合物可用于治疗慢性疼痛，广泛性疼痛障碍，白血病，癌症，慢性疼痛，化学疗法诱导的疼痛，癫痫，偏头痛，神经性疼痛，疱疹后神经痛，神经痛，疼痛，药物成瘾，药物解毒，阿尔茨海默病 ，多发性硬化症，多发性硬化症，不宁腿综合征（RLS），丛集性头痛，抑郁症，纤维肌痛，肌萎缩性侧索硬化（ALS），抽搐，部分发作，情绪稳定剂和双相障碍。

公开(公告)号：US09434729B2

公开(公告)日：2016-09-06

申请号：US14399177

申请日：2013-05-13

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： A61K31/194 ,  A61K31/198 ,  A61K31/202 ,  A61K31/42 ,  A61K31/425 ,  A61K31/4439 ,  A61K31/455 ,  A61K31/522 ,  A61K31/618 ,  C07D473/04 ,  A61K47/48

CPC分类号： C07D473/04 ,  A61K31/194 ,  A61K31/198 ,  A61K31/202 ,  A61K31/42 ,  A61K31/425 ,  A61K31/4439 ,  A61K31/455 ,  A61K31/522 ,  A61K31/618 ,  A61K47/48038 ,  A61K47/48061 ,  A61K47/542 ,  A61K47/545 ,  A61K2300/00

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of periodontitis and rheumatoid arthritis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物和用于治疗牙周炎和类风湿性关节炎的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。

公开(公告)号：US09403826B2

公开(公告)日：2016-08-02

申请号：US14399525

申请日：2013-02-02

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D473/04 ,  C07D473/08

CPC分类号： C07D473/04

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing inflammatory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of intermittent claudication resulting from obstructed arteries in the limbs, and vascular dementia, improves blood flow through peripheral blood vessels and therefore helps with blood circulation in the arms and legs (e.g. intermittent claudication), and the brain (hence its use in vascular dementia), venous disease, Peyronie's disease, neuropathic injuries, strokes, sickle cell disease, nausea and headaches in the mountains (altitude sickness), non-alcoholic steatohepatitis and alcoholic liver disease, fibrotic lesions induced by radiation therapy for breast cancer, cytokine release syndrome, cancer, type 1 diabetes and type 2 diabetes, asthma, bronchodilation, kidney diseases, renal protection, vascular ischemia, neuroprotection, vasodilation, Alzheimer's disease, dementia, stroke, and treatment of endometriosis.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物的药物组合物，以及用于治疗或预防炎症性疾病的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这种组合物可用于治疗由四肢阻塞的动脉引起的间歇性跛行，并且血管性痴呆，改善通过外周血管的血流量，并因此有助于手臂和腿部的血液循环（例如间歇性跛行）和脑（ 因此其用于血管性痴呆），静脉疾病，佩罗尼氏病，神经性损伤，中风，镰状细胞病，恶心和山脉头痛（高原病），非酒精性脂肪性肝炎和酒精性肝病，由放射治疗引起的纤维化病变 乳腺癌，细胞因子释放综合征，癌症，1型糖尿病和2型糖尿病，哮喘，支气管扩张，肾脏疾病，肾脏保护，血管缺血，神经保护，血管舒张，阿尔茨海默病，痴呆，中风和子宫内膜异位症的治疗。

公开(公告)号：US20160122332A1

公开(公告)日：2016-05-05

申请号：US14533113

申请日：2014-11-05

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D409/12 ,  A61K45/06 ,  A61K31/55

摘要： The invention relates to the compounds of formula I and formula IA or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I and formula IA; and methods for treating or preventing neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, trigeminal neuralgia, attention-deficit hyperactivity disorder (ADHD), schizophrenia, neuropathic pain, seizures, bipolar disorder, mania, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotonia, intermittent explosive disorder, borderline personality disorder, Myotonia congenita and post-traumatic stress disorder.

摘要翻译： 本发明涉及式I和式IA化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I和式IA化合物的药物组合物; 并且可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射的治疗或预防神经疾病的方法。 这种组合物可用于治疗癫痫，双相性精神障碍，三叉神经痛，注意力缺陷多动障碍（ADHD），精神分裂症，神经性疼痛，癫痫发作，双相情感障碍，躁狂症，幻肢综合征，复杂区域性疼痛综合征，阵发性极度疼痛症状 ，神经性肌张力障碍，间歇性爆发性疾病，边缘人格障碍，先天性肌强直和创伤后应激障碍。

公开(公告)号：US20160122293A1

公开(公告)日：2016-05-05

申请号：US14533118

申请日：2014-11-05

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07C281/04 ,  C07C271/22 ,  A61K47/48

CPC分类号： C07C243/18 ,  A61K47/542 ,  C07C281/02

摘要： The invention relates to the compound of or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing neuromuscular disorders and neurodegenerative diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, or parenteral-administration, or syrup, or injection. Such compositions may be used to treatment or management of neuromuscular disorders and neurodegenerative diseases such as Parkinson's disease, scleroderma, restless leg syndrome, hypertension and gestational hypertension.

摘要翻译： 本发明涉及其化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映异构体，立体异构体及其水合物。 包含有效量的式I化合物的药物组合物，以及用于治疗或预防神经肌肉疾病和神经变性疾病的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内或肠胃外给药或糖浆， 或注射。 这样的组合物可用于治疗或治疗神经肌肉疾病和神经变性疾病如帕金森病，硬皮病，不宁腿综合征，高血压和妊娠高血压。

公开(公告)号：US09284287B1

公开(公告)日：2016-03-15

申请号：US14533119

申请日：2014-11-05

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D285/135 ,  C07D417/12

CPC分类号： C07D285/135 ,  C07D417/12

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing or modulating carbonic anhydrase activity in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of glaucoma, epileptic seizures, Idiopathic intracranial hypertension (pseudotumor cerebri), altitude sickness, cystinuria, periodic paralysis and dural ectasia, congestive heart failure, drug induced edema, diuretic, intermittent claudication resulting from obstructed arteries in the limbs, and vascular dementia.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式I化合物的药物组合物，以及用于治疗或预防或调节疾病中碳酸酐酶活性的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆， 或注射。 这种组合物可用于治疗青光眼，癫痫发作，特发性颅内高压（假性脑瘤），高原病，胱氨酸尿症，周期性麻痹和硬脑膜扩张症，充血性心力衰竭，药物诱发的水肿，利尿，间断性跛行，由阻塞性动脉引起 四肢和血管性痴呆。

公开(公告)号：US20150353522A1

公开(公告)日：2015-12-10

申请号：US14827487

申请日：2015-08-17

申请人： Mahesh Kandula

发明人： Mahesh Kandula

IPC分类号： C07D339/04 ,  C07C237/22

CPC分类号： C07D339/04 ,  C07C237/08 ,  C07C237/22

摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I; and methods for treating or preventing moderate to severe pain, may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of muscle pain, spasticity, neuropathic pain, fibromyalgia, post-operative pain, muscle spasticity, headache, chronic pain, sub-chronic pain and local pain.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 药物组合物包含有效量的式I化合物; 以及用于治疗或预防中度至重度疼痛的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 此类组合物可用于治疗肌肉疼痛，痉挛症，神经性疼痛，纤维肌痛，手术后疼痛，肌肉痉挛，头痛，慢性疼痛，亚慢性疼痛和局部疼痛。