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1.发明授权公开(公告)号：US08114582B2
公开(公告)日：2012-02-14
申请号：US12163412
申请日：2008-06-27
申请人： Malford E. Cullum , Lloyd G. Simonson , Sylvia Z. Schade , Linda A. Lininger , Alan L. McArthur
发明人： Malford E. Cullum , Lloyd G. Simonson , Sylvia Z. Schade , Linda A. Lininger , Alan L. McArthur
CPC分类号： G01N21/6428 , G01N21/6445 , G01N33/582 , G01N2201/0221 , Y10T436/143333
摘要： The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample.
摘要翻译： 本发明涉及一种用于检测唾液或口腔液测试样品中感兴趣的生物物质的存在的方法，包括将所述测试样品与荧光标记的配体结合到所述生物物质上并检测荧光的变化 通过将所述荧光标记的配体结合到所述生物物质而产生的所述测试样品的极化。 在本发明主题的一个方面，所述方法包括用于将所述测试样品的荧光偏振与对照溶液的荧光偏振进行比较的附加步骤。 还提供了用于测量液体样品的荧光偏振的小型便携式设备。
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2.发明授权公开(公告)号：US07408640B2
公开(公告)日：2008-08-05
申请号：US10700868
申请日：2003-11-05
申请人： Malford E. Cullum , Lloyd G. Simonson , Sylvia Z. Schade , Linda A. Lininger , Alan L. McArthur
发明人： Malford E. Cullum , Lloyd G. Simonson , Sylvia Z. Schade , Linda A. Lininger , Alan L. McArthur
CPC分类号： G01N21/6428 , G01N21/6445 , G01N33/582 , G01N2201/0221 , Y10T436/143333
摘要： The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample.
摘要翻译： 本发明涉及一种用于检测唾液或口腔液测试样品中感兴趣的生物物质的存在的方法，包括将所述测试样品与荧光标记的配体结合到所述生物物质上并检测荧光的变化 通过将所述荧光标记的配体结合到所述生物物质而产生的所述测试样品的极化。 在本发明主题的一个方面，所述方法包括用于将所述测试样品的荧光偏振与对照溶液的荧光偏振进行比较的附加步骤。 还提供了用于测量液体样品的荧光偏振的小型便携式设备。
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3.发明申请FLUORESCENCE POLARIZATION INSTRUMENTS AND METHODS FOR DETECTION OF EXPOSURE TO BIOLOGICAL MATERIALS BY FLUORESCENCE POLARIZATION IMMUNOASSAY OF SALIVA, ORAL OR BODILY FLUIDS 有权荧光偏振仪和通过荧光偏振检测生物材料暴露的方法，SALIVA，口腔或体液的免疫荧光公开(公告)号：US20080318266A1
公开(公告)日：2008-12-25
申请号：US12163412
申请日：2008-06-27
申请人： Malford E. Cullum , Lloyd G. Simonson , Sylvia Z. Schade , Linda A. Lininger , Alan L. McArthur
发明人： Malford E. Cullum , Lloyd G. Simonson , Sylvia Z. Schade , Linda A. Lininger , Alan L. McArthur
CPC分类号： G01N21/6428 , G01N21/6445 , G01N33/582 , G01N2201/0221 , Y10T436/143333
摘要： The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said test sample produced by binding of said fluorescence-labeled ligand to said biological substance. In one aspect of the inventive subject matter, said method comprises additional steps for comparing the fluorescence polarization of said test sample with the fluorescence polarization of a control solution. Also provided is a miniaturized, portable apparatus for measuring the fluorescence polarization of a liquid sample.
摘要翻译： 本发明涉及一种用于检测唾液或口腔液测试样品中感兴趣生物物质的存在的方法，包括将所述测试样品与荧光标记的配体结合到所述生物物质上并检测荧光的变化 通过将所述荧光标记的配体结合到所述生物物质而产生的所述测试样品的极化。 在本发明主题的一个方面，所述方法包括用于将所述测试样品的荧光偏振与对照溶液的荧光偏振进行比较的附加步骤。 还提供了用于测量液体样品的荧光偏振的小型便携式设备。
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