Intraluminal device with a coating containing synthetic fish oil and a therapeutic agent
    1.
    发明授权
    Intraluminal device with a coating containing synthetic fish oil and a therapeutic agent 有权
    具有包含合成鱼油和治疗剂的涂层的管腔内装置

    公开(公告)号:US08460693B2

    公开(公告)日:2013-06-11

    申请号:US10494892

    申请日:2002-11-08

    IPC分类号: A61F2/00 A61F2/06

    摘要: The invention relates to an intraluminal device, in particular an intraluminal prosthesis, shunt, catheter or local drug delivery device. In order to increase the bio-compatibility of this device, it is provided with at least one coating. The coating contains a therapeutic agent which is comprised in a matrix that sticks to the intraluminal device. Instead of being formed by a little bio-compatible polymer, the matrix is formed by a bio-compatible oil or fat, such as cod-liver oil or olive oil. Preferably, the bio-compatible oil or fat further comprises alfa-tocopherol.

    摘要翻译: 本发明涉及腔内装置,特别是管腔内假体,分路器,导管或局部药物递送装置。 为了增加该装置的生物相容性,提供至少一个涂层。 涂层含有治疗剂,其包含在粘附于腔内装置的基质中。 代替由少量生物相容的聚合物形成,基质由生物相容的油或脂肪形成,例如鳕鱼肝油或橄榄油。 优选地,生物相容性油或脂肪还包含α-生育酚。

    Biocompatible coating of medical devices
    5.
    发明授权
    Biocompatible coating of medical devices 失效
    医疗器械的生物相容性涂层

    公开(公告)号:US08512734B2

    公开(公告)日:2013-08-20

    申请号:US11571723

    申请日:2005-07-05

    IPC分类号: A61F2/00 A61K9/00

    CPC分类号: A61L31/14 A61L31/10

    摘要: A coated implantable medical device is described, wherein the coating comprises a coating matrix and particles of one or more molecular sieves, preferably zeolite of zeogrid particles, optionally loaded with one or more bioactive agents. The coating matrix itself can function as a second drug-carrying interface. The coating comprising the molecular sieve material has an excellent biocompatibility and allows suitable drug delivery into the body of an animal, preferably a mammal and most preferably a human.

    摘要翻译: 描述了一种涂覆的可植入医疗装置,其中所述涂层包括涂覆基质和一种或多种分子筛的颗粒,优选沸石的锌离子颗粒,任选地加载一种或多种生物活性剂。 涂层基质本身可用作第二药物携带界面。 包含分子筛材料的涂层具有优异的生物相容性,并允许合适的药物输送到动物体内,优选哺乳动物,最优选人体。

    Biocompatible Coating of Medical Devices
    6.
    发明申请
    Biocompatible Coating of Medical Devices 失效
    医疗器械生物相容性涂层

    公开(公告)号:US20080003256A1

    公开(公告)日:2008-01-03

    申请号:US11571723

    申请日:2005-07-05

    IPC分类号: A61F2/82

    CPC分类号: A61L31/14 A61L31/10

    摘要: A coated implantable medical device is described, wherein the coating comprises a coating matrix and particles of one or more molecular sieves, preferably zeolite of zeogrid particles, optionally loaded with one or more bioactive agents. The coating matrix itself can function as a second drug-carrying interface. The coating comprising the molecular sieve material has an excellent biocompatibility and allows suitable drug delivery into the body of an animal, preferably a mammal and most preferably a human.

    摘要翻译: 描述了一种涂覆的可植入医疗装置,其中所述涂层包括涂覆基质和一种或多种分子筛的颗粒,优选沸石的锌离子颗粒,任选地加载一种或多种生物活性剂。 涂层基质本身可用作第二药物携带界面。 包含分子筛材料的涂层具有优异的生物相容性,并允许合适的药物输送到动物体内,优选哺乳动物,最优选人体。

    ZEOLITE MATERIALS AND SYNTHESIS METHOD THEREOF
    7.
    发明申请
    ZEOLITE MATERIALS AND SYNTHESIS METHOD THEREOF 审中-公开
    沸石材料及其合成方法

    公开(公告)号:US20100098623A1

    公开(公告)日:2010-04-22

    申请号:US12526414

    申请日:2008-02-07

    IPC分类号: C01B39/04 C01B39/40

    摘要: The present invention provides zeolites and zeolite-like material having an enhanced microporosity. It was found that such zeolites can be obtained using a zeolite synthesis method comprising the preparation of a gel or solution for the synthesis of a zeolite, said gel or solution comprising appropriate amounts of (i) a conventional monomeric or polymeric silica source and (ii) a molecular template as a microstructuring agent, characterized in that said gel or solution further comprises an organosilane compound having limited self-assembling capacity.

    摘要翻译: 本发明提供具有增强的微孔性的沸石和类沸石材料。 已经发现,这种沸石可以使用包括制备用于合成沸石的凝胶或溶液的沸石合成方法获得,所述凝胶或溶液包含适量的(i)常规单体或聚合二氧化硅源和(ii) )作为微结构化剂的分子模板,其特征在于所述凝胶或溶液还包含有限自组装能力的有机硅烷化合物。

    Process for the synthesis of alkylated aromatic hydrocarbons
    8.
    发明授权
    Process for the synthesis of alkylated aromatic hydrocarbons 失效
    合成烷基化芳烃的方法

    公开(公告)号:US5288936A

    公开(公告)日:1994-02-22

    申请号:US768988

    申请日:1992-01-24

    摘要: Process for the synthesis of aromatic alkylated hydrocarbons with a saturated alkyl chain including at least four carbon atoms, according to which an aromatic hydrocarbon, replaced by an alkyl group with a short saturated chain comprising one to three carbon atoms, is made to react with an olefin in the presence of a catalyst made up of at least one alkaline metal or a alkaline metal hydride impregnated on an alumina support. The process is characterised by the fact that the catalyst is prepared in the reaction medium in the presence of the aromatic hydrocarbon with a short alkyl chain by mixing anhydrous alumina with the alkaline metal hydride or with the alkaline metal, and then the olefin is introduced in order to start the reaction.

    摘要翻译: PCT No.PCT / BE90 / 00022 Sec。 371日期:1992年1月24日 102(e)日期1992年1月24日PCT 1990年5月25日PCT PCT。 WO90 / 14323 PCT出版物 日本1990年11月29日。用于合成具有包含至少四个碳原子的饱和烷基链的芳族烷基化烃的方法,根据该方法,芳族烃被具有一个至少三个碳原子的短饱和链的烷基取代 ,在由至少一种浸渍在氧化铝载体上的碱金属或碱金属氢化物组成的催化剂存在下与烯烃反应。 该方法的特征在于,通过将无水氧化铝与碱金属氢化物或碱金属混合,在具有短烷基链的芳族烃存在下,在反应介质中制备催化剂,然后将烯烃引入 开始反应。