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公开(公告)号：US08252794B2
公开(公告)日：2012-08-28
申请号：US11707008
申请日：2007-02-16
申请人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K31/495 , A61K31/435 , A61K31/38
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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公开(公告)号：US08399466B2
公开(公告)日：2013-03-19
申请号：US12782514
申请日：2010-05-18
申请人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K31/495 , A61K31/435 , A61K31/38
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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公开(公告)号：US20100226993A1
公开(公告)日：2010-09-09
申请号：US12782514
申请日：2010-05-18
申请人： Masaharu TAKIGAWA , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu TAKIGAWA , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K9/14 , A61K31/4418 , A61P19/00 , A61K31/502 , A61K31/27 , A61K31/44 , A61K31/4409 , A61K31/277 , A61K31/40 , A61K31/5377 , A61K31/4725 , A61P19/10
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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公开(公告)号：US20070155652A1
公开(公告)日：2007-07-05
申请号：US11707008
申请日：2007-02-16
申请人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
发明人： Masaharu Takigawa , Naoki Sakurai , Toshiki Takagi , Noriyuki Yanaka , Yuji Horikiri , Takashi Tamura
IPC分类号： A61K38/39
CPC分类号： A61K31/27 , A61K9/1647 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551
摘要： A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
摘要翻译： 提供了一种用于软骨疾病的再生治疗的组合物，其包含PDE4抑制剂作为活性成分，特别是包含PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部施用于受影响软骨的形式时 可以提供在软骨的再生处理中显示出极好的效果的药物组合物，例如微球制剂。
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公开(公告)号：US20080031958A1
公开(公告)日：2008-02-07
申请号：US11826921
申请日：2007-07-19
CPC分类号： A61K31/502 , A61K9/1647 , A61K31/27 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61L27/227 , A61L27/58 , A61L2430/02
摘要： A composition for accelerating fracture healing, which has a PDE4 inhibitor as an active ingredient, specifically a composition having a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suitable for local administration such as a microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in the early healing of bone fracture. The composition is useful in healing of refractory fracture of elderly people and diabetic or osteoporosis patients.
摘要翻译： 提供一种用于加速骨折愈合的组合物，其具有PDE4抑制剂作为活性成分，特别是具有PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部给药的形式时，例如微球制剂 可以提供在骨折早期愈合中表现出优异效果的药物组合物。 该组合物可用于老年人和糖尿病或骨质疏松症患者的难治性骨折愈合。
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公开(公告)号：US07659273B2
公开(公告)日：2010-02-09
申请号：US11826921
申请日：2007-07-19
IPC分类号： A61K31/495 , A61K31/435 , A61K31/38
CPC分类号： A61K31/502 , A61K9/1647 , A61K31/27 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4166 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4453 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61L27/227 , A61L27/58 , A61L2430/02
摘要： A composition for accelerating fracture healing, which has a PDE4 inhibitor as an active ingredient, specifically a composition having a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suitable for local administration such as a microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in the early healing of bone fracture. The composition is useful in healing of refractory fracture of elderly people and diabetic or osteoporosis patients.
摘要翻译： 提供一种用于加速骨折愈合的组合物，其具有PDE4抑制剂作为活性成分，特别是具有PDE4抑制剂和生物相容性和生物可降解聚合物的组合物，该组合物当配制成适于局部给药的形式时，例如微球制剂 可以提供在骨折早期愈合中表现出优异效果的药物组合物。 该组合物可用于老年人和糖尿病或骨质疏松症患者的难治性骨折愈合。
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