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公开(公告)号：US07265135B2
公开(公告)日：2007-09-04
申请号：US10757625
申请日：2004-01-14
申请人： Michael Bogenstaetter , Nicholas I. Carruthers , Jill A. Jablonowski , Timothy W. Lovenberg , Kiev S. Ly
发明人： Michael Bogenstaetter , Nicholas I. Carruthers , Jill A. Jablonowski , Timothy W. Lovenberg , Kiev S. Ly
IPC分类号： C07D401/12 , C07D401/14 , C07D233/84 , A61K31/4178 , A61P25/08
CPC分类号： C07D401/12 , C07D233/70 , C07D233/84 , C07D403/12
摘要： The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds and methods of using them in the treatment of neurological disorders and other disorders and conditions mediated by the histamine H3 receptor.
摘要翻译： 本发明涉及式（I）的新型2-氧基，2-氨基和2-硫代咪唑化合物：其中所有变量如本文所定义，含有该化合物的药物组合物及其用于治疗神经障碍的方法 和由组胺H 3 N受体介导的其它病症和病症。
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公开(公告)号：US06803362B2
公开(公告)日：2004-10-12
申请号：US10094357
申请日：2002-03-08
申请人： Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： A61K3133
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译： 杂环化合物及其制备方法和使用方法。
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公开(公告)号：US07317025B2
公开(公告)日：2008-01-08
申请号：US10949055
申请日：2004-09-24
申请人： Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
发明人： Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
IPC分类号： A61K31/445 , A61K31/405 , C07D209/00 , C07D209/02 , C07D209/04 , C07D211/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译： 本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防排卵和不育症。
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公开(公告)号：US20080132540A1
公开(公告)日：2008-06-05
申请号：US11942387
申请日：2007-11-19
申请人： Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
发明人： Nicholas I. Carruthers , Wenying Chai , Scott L. Dax , Jill A. Jablonowski , Xiaobing Li , Timothy W. Lovenberg , William V. Murray , Dale A. Rudolph , Mark Seierstad , Mark A. Youngman
IPC分类号： A61K31/4545 , A61K31/404 , A61P25/24 , A61P3/04 , A61P25/00 , A61K31/454
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译： 本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防排卵和不育症。
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公开(公告)号：US08273762B2
公开(公告)日：2012-09-25
申请号：US12792675
申请日：2010-06-02
申请人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
发明人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
IPC分类号： C07D487/02 , A61K31/4353
CPC分类号： C07D471/04
摘要： Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
摘要翻译： 某些六氢 - 吡咯并 - 异喹啉化合物是可用于治疗组胺H3受体和5-羟色胺介导的疾病的组胺H3受体和5-羟色胺转运体调节剂。
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6.发明授权Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists 失效使用2-芳氧基烷基氨基苯并唑和2-芳氧基烷基氨基苯并噻唑作为H3拮抗剂的方法公开(公告)号：US06436939B2
公开(公告)日：2002-08-20
申请号：US09821215
申请日：2001-03-29
IPC分类号： A61K31495
CPC分类号： C07D209/12 , A61K31/423 , A61K31/428 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The invention features methods of using pharmaceutically-active 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzthiazoles and derivatives.
摘要翻译： 本发明的特征在于使用药用活性2-芳氧基烷基氨基苯并唑和2-芳氧基烷基氨基苯并噻唑及其衍生物的方法。
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公开(公告)号：US20100240648A1
公开(公告)日：2010-09-23
申请号：US12792675
申请日：2010-06-02
申请人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
发明人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
IPC分类号： A61K31/5377 , C07D221/06 , A61K31/437 , C07D413/14 , A61P25/24
CPC分类号： C07D471/04
摘要： Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
摘要翻译： 某些六氢 - 吡咯并 - 异喹啉化合物是可用于治疗组胺H3受体和5-羟色胺介导的疾病的组胺H3受体和5-羟色胺转运体调节剂。
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公开(公告)号：US20120321559A1
公开(公告)日：2012-12-20
申请号：US13594376
申请日：2012-08-24
申请人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
发明人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
IPC分类号： A61K31/4545 , A61P25/00 , A61K31/5377 , A61P25/24 , C07D471/04 , A61K51/04
CPC分类号： C07D471/04
摘要： Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
摘要翻译： 某些六氢 - 吡咯并 - 异喹啉化合物是可用于治疗组胺H3受体和5-羟色胺介导的疾病的组胺H3受体和5-羟色胺转运体调节剂。
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公开(公告)号：US07754882B2
公开(公告)日：2010-07-13
申请号：US11424734
申请日：2006-06-16
申请人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
发明人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
IPC分类号： C07D471/04 , C07D265/06 , A61K31/437
CPC分类号： C07D471/04
摘要： Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
摘要翻译： 某些六氢 - 吡咯并 - 异喹啉化合物是可用于治疗组胺H3受体和5-羟色胺介导的疾病的组胺H3受体和5-羟色胺转运体调节剂。
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公开(公告)号：US20090263322A1
公开(公告)日：2009-10-22
申请号：US12494754
申请日：2009-06-30
申请人： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
发明人： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
IPC分类号： A61K31/437 , C07D221/04 , C07D401/14 , A61K31/496 , A61K51/00 , A61P11/00 , A61P25/00
CPC分类号： C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
摘要： The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
摘要翻译： 本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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