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    Drug Delivery Device
    1.
    发明申请
    Drug Delivery Device 审中-公开
    药物输送装置

    公开(公告)号：US20130204203A1

    公开(公告)日：2013-08-08

    申请号：US13576671

    申请日：2011-03-16

    申请人： Lutz Mueller ,  Claudia Matthias ,  Michael Helmer ,  Steffen Raab ,  Axel Forstreutter

    发明人： Lutz Mueller ,  Claudia Matthias ,  Michael Helmer ,  Steffen Raab ,  Axel Forstreutter

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31548 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31595 ,  A61M2005/2488 ,  A61M2005/2492 ,  A61M2207/00 ,  Y10T29/49826

    摘要： The present invention relates to a drug delivery device for dispensing of a dose of a medicinal product, comprising: a first housing component (12, 52; 62) adapted to receive a cartridge (16) comprising the medicinal product and further comprising a piston (18) slidably arranged therein in an axial direction, a second housing component (14; 54; 64) adapted to receive a dose dispensing mechanism having a piston rod (20) to be operably engaged with the cartridge's piston (18), wherein the first and the second housing components (12, 14; 52, 54; 62, 64) are displaceably arranged in axial direction relative to each other for reducing an axial distance (34) between the piston (18) and the piston rod (20) to a pre-defined degree, and an interlock means (30) adapted to interact with at least one of first and second housing components (12, 14; 52, 54; 62, 64) for mutually locking into position first and second housing components (12, 14; 52, 54; 62, 64).

    摘要翻译： 本发明涉及用于分配药物产品剂量的药物递送装置，包括：第一壳体部件（12,52; 62），适于接收包括药物产品的药筒（16），并且还包括活塞（ 18），其沿轴向方向可滑动地布置在其中;第二壳体部件（14; 54; 64），其适于接收剂量分配机构，所述剂量分配机构具有可与所述药筒活塞（18）可操作地接合的活塞杆（20），其中所述第一 并且所述第二壳体部件（12,14; 52,54; 62,64）可相对于彼此沿轴向方向可移位地设置，以便减少所述活塞（18）和所述活塞杆（20）之间的轴向距离（34） 以及互锁装置（30），其适于与第一和第二壳体部件（12,14; 52,54; 62,64）中的至少一个相互作用，以相互锁定到位置第一和第二壳体部件（ 12,14; 52,54; 62,64）。

    DRUG DELIVERY DEVICE
    2.
    发明申请
    DRUG DELIVERY DEVICE 有权
    药物递送装置

    公开(公告)号：US20130041325A1

    公开(公告)日：2013-02-14

    申请号：US13512180

    申请日：2010-12-02

    申请人： Michael Helmer ,  Steffen Raab

    发明人： Michael Helmer ,  Steffen Raab

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31555 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/3156 ,  A61M5/3158 ,  A61M5/31593 ,  A61M2005/31506

    摘要： A drug delivery device comprises a housing and a piston rod arranged in the housing. The piston rod is adapted to be moved along an axial direction to dispense a fluid. A drive member arranged in the housing is operatively coupled to the piston rod and adapted to set up a dose of fluid for dispense in response to a first movement. The drive member is also adapted to move the piston rod to dispense the dose in response to a second movement. The drug delivery device also comprises a pre-dispensing drive member operatively coupled to the drive member and the housing and adapted to move at least the drive member by a pre-dispensing distance between its first and second movement.

    摘要翻译： 药物输送装置包括设置在壳体中的壳体和活塞杆。 活塞杆适于沿轴向移动以分配流体。 布置在壳体中的驱动构件可操作地联接到活塞杆并且适于设置响应于第一运动而分配的剂量的流体。 驱动构件还适于移动活塞杆以响应于第二运动而分配剂量。 药物递送装置还包括预分配驱动构件，其可操作地联接到驱动构件和壳体并且适于在其第一和第二运动之间通过预分配距离至少移动驱动构件。

    Drug delivery device
    3.
    发明授权
    Drug delivery device 有权
    给药装置

    公开(公告)号：US09022992B2

    公开(公告)日：2015-05-05

    申请号：US13512180

    申请日：2010-12-02

    申请人： Michael Helmer ,  Steffen Raab

    发明人： Michael Helmer ,  Steffen Raab

    IPC分类号： A61M5/00 ,  A61M5/315 ,  A61M5/31 ,  A61M5/24

    CPC分类号： A61M5/31555 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/3156 ,  A61M5/3158 ,  A61M5/31593 ,  A61M2005/31506

    摘要： A drug delivery device comprises a housing and a piston rod arranged in the housing. The piston rod is adapted to be moved along an axial direction to dispense a fluid. A drive member arranged in the housing is operatively coupled to the piston rod and adapted to set up a dose of fluid for dispense in response to a first movement. The drive member is also adapted to move the piston rod to dispense the dose in response to a second movement. The drug delivery device also comprises a pre-dispensing drive member operatively coupled to the drive member and the housing and adapted to move at least the drive member by a pre-dispensing distance between its first and second movement.

    摘要翻译： 药物输送装置包括设置在壳体中的壳体和活塞杆。 活塞杆适于沿轴向移动以分配流体。 布置在壳体中的驱动构件可操作地联接到活塞杆并且适于设置响应于第一运动而分配的剂量的流体。 驱动构件还适于移动活塞杆以响应于第二运动而分配剂量。 药物递送装置还包括预分配驱动构件，其可操作地联接到驱动构件和壳体并且适于在其第一和第二运动之间通过预分配距离至少移动驱动构件。

    DRUG DELIVERY DEVICE AND METHOD OF ASSEMBLING THE SAME
    4.
    发明申请
    DRUG DELIVERY DEVICE AND METHOD OF ASSEMBLING THE SAME 审中-公开
    药物递送装置及其装配方法

    公开(公告)号：US20130338600A1

    公开(公告)日：2013-12-19

    申请号：US14002179

    申请日：2012-03-16

    申请人： Michael Helmer ,  Claudia Matthias ,  Lutz Mueller ,  Steffen Raab ,  Peter Nober ,  Reza Shahbazfar ,  Benjamin Schäfer ,  Leo Zeimetz

    发明人： Michael Helmer ,  Claudia Matthias ,  Lutz Mueller ,  Steffen Raab ,  Peter Nober ,  Reza Shahbazfar ,  Benjamin Schäfer ,  Leo Zeimetz

    IPC分类号： A61M5/31

    CPC分类号： A61M5/31 ,  A61M5/24 ,  Y10T29/49826

    摘要： A drug delivery device for dispensing of a dose of a medicinal product is presented comprising a first housing component having a receptacle being oval- or elliptically shaped in radial cross section and being adapted to at least partially receive an insert portion of a second housing component being at least partially insertable into said first housing component along an axial direction, wherein the insert portion is oval- or elliptically shaped in radial cross section. The outside dimension or an at least one outside diameter of the insert portion is at least in sections larger than a corresponding inner dimension or an at least one inner diameter of the receptacle and wherein the insert portion and the receptacle are adapted to generate a radially acting mutual clamping of first and second housing components in a pre-fixing assembly configuration.

    摘要翻译： 提供了一种用于分配药物产品剂量的药物递送装置，其包括第一壳体部件，所述第一壳体部件具有椭圆形或椭圆形的径向横截面并且适于至少部分地容纳第二壳体部件的插入部分， 至少部分地沿着轴向方向插入所述第一壳体部件中，其中所述插入部分在径向横截面上呈椭圆形或椭圆形。 插入部分的外部尺寸或至少一个外径至少部分地大于插座的对应内部尺寸或至少一个内径，并且其中插入部分和插座适于产生径向作用 将第一和第二壳体部件相互夹紧在预定义组件构造中。

    Training mechanism for drug delivery device
    5.
    发明授权
    Training mechanism for drug delivery device 有权
    药物输送装置的培训机制

    公开(公告)号：US09336690B2

    公开(公告)日：2016-05-10

    申请号：US13989881

    申请日：2011-12-06

    申请人： Michael Helmer ,  Peter Nober ,  Christoph Garthen ,  Christian Dexheimer ,  Benjamin Schaefer

    发明人： Michael Helmer ,  Peter Nober ,  Christoph Garthen ,  Christian Dexheimer ,  Benjamin Schaefer

    IPC分类号： G09B23/28 ,  A61M5/24 ,  A61M5/315

    CPC分类号： G09B23/285 ,  A61M5/24 ,  A61M5/31505 ,  A61M5/31511 ,  A61M5/31513 ,  A61M2005/31508 ,  G09B23/28

    摘要： The present invention relates to a cartridge for a drug delivery device comprising of a body of substantially cylindrical shape, a piston slidably disposed in the body along two opposite axial directions, along a distal and along a proximal direction, and at least one friction means operably engaged with the piston to generate a pre-defined friction force between the piston and an inside wall of the body, when the piston is displaced relative to the body, wherein in response to an axial displacement of the piston relative to the body in distal direction and in proximal direction, the at least one friction means is adapted to generate respective proximal and distal friction forces that are different in magnitude.

    摘要翻译： 本发明涉及一种用于药物输送装置的药筒，其包括基本上圆柱形的主体，沿着远端和近端方向沿着两个相对的轴向方向可滑动地设置在主体内的活塞，以及可操作地至少一个摩擦装置 当活塞相对于主体移动时，活塞与活塞接合以在活塞和主体的内壁之间产生预定义的摩擦力，其中响应于活塞相对于主体在远端方向上的轴向位移 并且在近侧方向上，所述至少一个摩擦装置适于产生大小不同的相应的近端和远端摩擦力。

    DRIVE MECHANISM FOR DRUG DELIVERY DEVICES
    9.
    发明申请
    DRIVE MECHANISM FOR DRUG DELIVERY DEVICES 有权
    用于药物递送装置的驱动机构

    公开(公告)号：US20130023831A1

    公开(公告)日：2013-01-24

    申请号：US13500416

    申请日：2010-10-08

    申请人： Michael Helmer ,  Claudia Matthias ,  Peter Nober ,  Reza Shahbazfar ,  Benjamin Schaefer ,  Leo Zeimetz

    发明人： Michael Helmer ,  Claudia Matthias ,  Peter Nober ,  Reza Shahbazfar ,  Benjamin Schaefer ,  Leo Zeimetz

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31515 ,  A61M5/24 ,  A61M5/3146 ,  A61M2005/2407 ,  A61M2207/00

    摘要： The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicinal product, comprising: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, an adjusting assembly adapted to eliminate axial clearance between the piston and the piston rod, wherein the adjusting assembly comprises at least one radially extending spike element for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.

    摘要翻译： 本发明涉及一种药剂输送装置的驱动机构，用于分配药剂的剂量，其特征在于，包括：用于容纳产品的药筒的保持器，所述药筒具有沿轴向可滑动地设置的活塞，活塞杆 与药筒的活塞可操作地接合以分配一定剂量的药用产品，调节组件适于消除活塞和活塞杆之间的轴向间隙，其中调节组件包括至少一个径向延伸的尖钉元件，用于相互锁定 定位活塞和活塞杆，而不管活塞和活塞杆之间的相对距离如何。

    Piston rod assembly for a drug delivery device
    10.
    发明授权
    Piston rod assembly for a drug delivery device 有权
    用于药物输送装置的活塞杆组件

    公开(公告)号：US08986259B2

    公开(公告)日：2015-03-24

    申请号：US12791499

    申请日：2010-06-01

    申请人： Michael Helmer ,  Christoph Eissengarthen ,  Winfried Huthmacher ,  Carsten Mosebach ,  Leo Zeimetz

    发明人： Michael Helmer ,  Christoph Eissengarthen ,  Winfried Huthmacher ,  Carsten Mosebach ,  Leo Zeimetz

    IPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/31

    CPC分类号： A61M5/31515 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31511 ,  A61M5/31555 ,  A61M5/3156 ,  A61M5/3158 ,  A61M2005/2407 ,  A61M2005/3152 ,  A61M2207/00 ,  Y10T29/49826

    摘要： Various embodiments of piston rod assemblies, drug delivery devices making use of such piston rod assemblies, and methods for assembling such piston rod assemblies and drug delivery devices are provided. In one embodiment, a piston rod assembly for a drug delivery device is provided, wherein the piston rod assembly is configured to engage a piston of a medicament cartridge. The piston rod assembly comprises (i) a piston rod, (ii) at least one adjusting member displaceably engaged with a distal end section of the piston rod, wherein the at least one adjusting member is displaceable along a long axis of the piston rod, and (iii) at least one interlock member configured to mutually lock the at least one adjusting member and the piston rod in an arbitrary relative axial position.

    摘要翻译： 提供了使用这种活塞杆组件的活塞杆组件，药物输送装置的各种实施例，以及用于组装这种活塞杆组件和药物输送装置的方法。 在一个实施例中，提供了一种用于药物输送装置的活塞杆组件，其中活塞杆组件构造成与药剂盒的活塞接合。 活塞杆组件包括（i）活塞杆，（ii）可移动地与活塞杆的远端部分接合的至少一个调节构件，其中所述至少一个调节构件可沿着活塞杆的长轴线移动， 和（iii）至少一个互锁构件，构造成将至少一个调节构件和活塞杆相互锁定在任意的相对轴向位置。