公开(公告)号：US11357864B2

公开(公告)日：2022-06-14

申请号：US16470897

申请日：2017-12-19

Applicant: NOVARTIS AG

Inventor： Ben Wen ,  Anthony E. Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20170239296A1

公开(公告)日：2017-08-24

申请号：US15409292

申请日：2017-01-18

Applicant: NOVARTIS AG

Inventor： Anthony E. Boitano ,  Michael Cooke ,  Shifeng Pan ,  Peter G. Schultz ,  John Tellew ,  Yongqin Wan ,  Xing Wang

IPC: A61K35/28 ,  A61K9/00 ,  C12N5/0789 ,  A61K31/52

CPC classification number: A61K35/28 ,  A61K9/0019 ,  A61K31/52 ,  A61K38/00 ,  A61K2035/124 ,  C07D473/16 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C12N5/0647 ,  C12N2501/38 ,  C12N2501/60

Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.