公开(公告)号：US10280139B2

公开(公告)日：2019-05-07

申请号：US15822930

申请日：2017-11-27

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia Ou ,  Shifeng Pan ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

IPC: C07D207/09 ,  C07K5/02 ,  A61K47/68 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07K16/32

Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：US10392421B2

公开(公告)日：2019-08-27

申请号：US15961531

申请日：2018-04-24

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Yunho Jin ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

IPC: C07K5/02 ,  A61K47/68 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：US09938323B2

公开(公告)日：2018-04-10

申请号：US15524197

申请日：2015-11-05

Applicant: NOVARTIS AG

Inventor： Jan Grunewald ,  Yunho Jin ,  Weijia Ou ,  Tetsuo Uno

IPC: A61K38/00 ,  C07K7/64 ,  C07K16/22 ,  C07K16/30

CPC classification number: C07K7/64 ,  C07K16/22 ,  C07K16/30 ,  C07K2319/30

Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:

公开(公告)号：US20180155281A1

公开(公告)日：2018-06-07

申请号：US15822930

申请日：2017-11-27

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia OU ,  Shifeng Pan ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

IPC: C07D207/09 ,  C07D401/12 ,  A61K47/68 ,  C07K16/32 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12

CPC classification number: C07D207/09 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07K5/0205 ,  C07K16/32

Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：US10787480B2

公开(公告)日：2020-09-29

申请号：US16439204

申请日：2019-06-12

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Yunho Jin ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

IPC: C07K5/02 ,  A61K47/68 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.