公开(公告)号：US20170088546A1

公开(公告)日：2017-03-30

申请号：US15311086

申请日：2015-05-14

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Rene BEERLI ,  Simona COTESTA ,  Pier Luca D'ALESSANDRO ,  Rene LATTMANN ,  Robert Alexander PULZ ,  Thomas J. TROXLER

IPC: C07D413/12 ,  A61K31/423 ,  A61K31/424 ,  C07D498/04

CPC classification number: C07D413/12 ,  A61K31/423 ,  A61K31/424 ,  C07D498/04

Abstract: The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.

公开(公告)号：US20220387602A1

公开(公告)日：2022-12-08

申请号：US17642285

申请日：2020-09-14

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Valerie BROENNIMANN ,  Pier Luca D'ALESSANDRO ,  Lionel DOUMAMPOUOM-METOUL ,  Marie-Line GOUDE ,  Christina HEBACH ,  Gregory John HOLLINGWORTH ,  Ingrid Karen Jennifer JEULIN ,  Louise Clare KIRMAN ,  Julien LORBER ,  Fupeng MA ,  Anna VULPETTI ,  Ken YAMADA ,  Thomas ZOLLER

IPC: A61K47/55 ,  A61K47/54

Abstract: Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.