公开(公告)号：US20120202771A1

公开(公告)日：2012-08-09

申请号：US13499941

申请日：2010-10-07

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Tamiko Nishino ,  Kisato Kusano ,  Tadaaki Miyazaki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Tamiko Nishino ,  Kisato Kusano ,  Tadaaki Miyazaki

IPC分类号： A61K31/716 ,  A61P31/16 ,  C08B37/00

CPC分类号： A61K39/0208 ,  A61K9/0095 ,  A61K31/716 ,  A61K35/74

摘要： Provided is a therapeutic agent for an influenza virus infectious disease, which utilizes an active ingredient derived from a natural product and has an excellent effect. The therapeutic agent for an influenza virus infectious disease includes, as an active ingredient, a β-glucan-containing composition obtained from a culture of a microorganism belonging to Aureobasidium sp. The therapeutic agent is capable of preventing an influenza virus infectious disease from becoming serious and is capable of promoting the healing of the influenza virus infectious disease.

摘要翻译： 本发明提供一种流感病毒感染性疾病的治疗剂，其利用来自天然产物的活性成分，具有优异的效果。 用于流感病毒感染性疾病的治疗剂包括作为活性成分的含有葡聚糖的组合物，其由属于Aureobasidium sp。的微生物的培养物获得。 治疗剂能够防止流感病毒感染性疾病变得严重，能够促进流感病毒感染性疾病的愈合。

公开(公告)号：US20120329154A1

公开(公告)日：2012-12-27

申请号：US13512502

申请日：2010-12-03

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

IPC分类号： C12N5/0786

CPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K36/06 ,  C12N1/38 ,  C12R1/645 ,  A61K2300/00

摘要： Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.

摘要翻译： 公开了使用衍生自天然产物的活性成分在巨噬细胞中促进细胞因子产生的高效巨噬细胞吞噬活化组合物和/或组合物。 使用通过培养属于Aureobasidium属（Aureobasidium sp。）的微生物获得的培养物作为在巨噬细胞中促进细胞因子产生的巨噬细胞吞噬活化组合物和/或组合物的活性成分。 通过巨噬细胞吞噬活化组合物和/或组合物促进巨噬细胞中的细胞因子产生，可以激活巨噬细胞吞噬作用，并且可以促进巨噬细胞中的细胞因子产生。 特别地，巨噬细胞吞噬活化组合物可以激活由抗癌药物损伤或破坏的癌细胞或细胞的吞噬作用。

公开(公告)号：US08802433B2

公开(公告)日：2014-08-12

申请号：US13512502

申请日：2010-12-03

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

IPC分类号： C12N5/07 ,  A61K31/4745 ,  A61K31/513 ,  C12R1/645 ,  C12N1/38 ,  A61K36/06

CPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K36/06 ,  C12N1/38 ,  C12R1/645 ,  A61K2300/00

摘要： Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.

摘要翻译： 公开了使用衍生自天然产物的活性成分在巨噬细胞中促进细胞因子产生的高效巨噬细胞吞噬活化组合物和/或组合物。 使用通过培养属于Aureobasidium属（Aureobasidium sp。）的微生物获得的培养物作为在巨噬细胞中促进细胞因子产生的巨噬细胞吞噬活化组合物和/或组合物的活性成分。 通过巨噬细胞吞噬活化组合物和/或组合物促进巨噬细胞中的细胞因子产生，可以激活巨噬细胞吞噬作用，并且可以促进巨噬细胞中的细胞因子产生。 特别地，巨噬细胞吞噬活化组合物可以激活由抗癌药物损伤或破坏的癌细胞或细胞的吞噬作用。