公开(公告)号：US20120329154A1

公开(公告)日：2012-12-27

申请号：US13512502

申请日：2010-12-03

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

IPC分类号： C12N5/0786

CPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K36/06 ,  C12N1/38 ,  C12R1/645 ,  A61K2300/00

摘要： Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.

摘要翻译： 公开了使用衍生自天然产物的活性成分在巨噬细胞中促进细胞因子产生的高效巨噬细胞吞噬活化组合物和/或组合物。 使用通过培养属于Aureobasidium属（Aureobasidium sp。）的微生物获得的培养物作为在巨噬细胞中促进细胞因子产生的巨噬细胞吞噬活化组合物和/或组合物的活性成分。 通过巨噬细胞吞噬活化组合物和/或组合物促进巨噬细胞中的细胞因子产生，可以激活巨噬细胞吞噬作用，并且可以促进巨噬细胞中的细胞因子产生。 特别地，巨噬细胞吞噬活化组合物可以激活由抗癌药物损伤或破坏的癌细胞或细胞的吞噬作用。

公开(公告)号：US08802433B2

公开(公告)日：2014-08-12

申请号：US13512502

申请日：2010-12-03

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Yukitoshi Nagahara ,  Hidekazu Tamegai ,  Tadaaki Miyazaki

IPC分类号： C12N5/07 ,  A61K31/4745 ,  A61K31/513 ,  C12R1/645 ,  C12N1/38 ,  A61K36/06

CPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K36/06 ,  C12N1/38 ,  C12R1/645 ,  A61K2300/00

摘要： Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.

摘要翻译： 公开了使用衍生自天然产物的活性成分在巨噬细胞中促进细胞因子产生的高效巨噬细胞吞噬活化组合物和/或组合物。 使用通过培养属于Aureobasidium属（Aureobasidium sp。）的微生物获得的培养物作为在巨噬细胞中促进细胞因子产生的巨噬细胞吞噬活化组合物和/或组合物的活性成分。 通过巨噬细胞吞噬活化组合物和/或组合物促进巨噬细胞中的细胞因子产生，可以激活巨噬细胞吞噬作用，并且可以促进巨噬细胞中的细胞因子产生。 特别地，巨噬细胞吞噬活化组合物可以激活由抗癌药物损伤或破坏的癌细胞或细胞的吞噬作用。

公开(公告)号：US20120202771A1

公开(公告)日：2012-08-09

申请号：US13499941

申请日：2010-10-07

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Tamiko Nishino ,  Kisato Kusano ,  Tadaaki Miyazaki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Yasuhiro Nikawa ,  Tamiko Nishino ,  Kisato Kusano ,  Tadaaki Miyazaki

IPC分类号： A61K31/716 ,  A61P31/16 ,  C08B37/00

CPC分类号： A61K39/0208 ,  A61K9/0095 ,  A61K31/716 ,  A61K35/74

摘要： Provided is a therapeutic agent for an influenza virus infectious disease, which utilizes an active ingredient derived from a natural product and has an excellent effect. The therapeutic agent for an influenza virus infectious disease includes, as an active ingredient, a β-glucan-containing composition obtained from a culture of a microorganism belonging to Aureobasidium sp. The therapeutic agent is capable of preventing an influenza virus infectious disease from becoming serious and is capable of promoting the healing of the influenza virus infectious disease.

摘要翻译： 本发明提供一种流感病毒感染性疾病的治疗剂，其利用来自天然产物的活性成分，具有优异的效果。 用于流感病毒感染性疾病的治疗剂包括作为活性成分的含有葡聚糖的组合物，其由属于Aureobasidium sp。的微生物的培养物获得。 治疗剂能够防止流感病毒感染性疾病变得严重，能够促进流感病毒感染性疾病的愈合。

公开(公告)号：US08183031B2

公开(公告)日：2012-05-22

申请号：US11575047

申请日：2005-08-03

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Koji Kubota

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Koji Kubota

IPC分类号： A01N63/00 ,  A01N63/04 ,  C12N1/00

CPC分类号： A61K8/73 ,  A23L29/271 ,  A23L33/10 ,  A23V2002/00 ,  A61Q19/00 ,  C12R1/645 ,  Y10S435/911 ,  A23V2250/5034 ,  A23V2200/318 ,  A23V2200/30

摘要： It is intended to utilize β-glucan produced by a bacterium belonging to Aureobasidium sp. From a bacterium belonging to Aureobasidium sp., a mutant with little pigment accumulation is constructed by a mutagenesis means of, for example, irradiating with ultraviolet light or treating with a mutagen. A culture obtained by culturing this mutant in a liquid culture medium is usable as a composition with a large β-glucan content without showing any intense dark green color caused by the accumulation of melanin-like pigments. This composition may be taken as such as a functional food having the physiologically active functions of the β-glucan-containing composition. Alternatively, it may be added to foods, drinks. food additives, cosmetics and so on.

摘要翻译： 用于利用属于Aureobasidium sp。的细菌产生的葡聚糖。 从属于Aureobasidium sp。的细菌，通过例如用紫外线照射或用诱变剂处理的诱变方法构建具有少量颜料积累的突变体。 通过在液体培养基中培养该突变体获得的培养物可用作具有大量葡萄糖含量的组合物，而不会由黑色素样颜料的积累引起任何强烈的深绿色。 该组合物可以作为具有含葡聚糖组合物的生理活性功能的功能性食品。 或者，它可以添加到食物，饮料中。 食品添加剂，化妆品等。

公开(公告)号：US20080293669A1

公开(公告)日：2008-11-27

申请号：US11575047

申请日：2005-08-03

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Koji Kubota

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Koji Kubota

IPC分类号： A61K31/719 ,  C12N1/20 ,  A61P17/00 ,  A23L1/48

CPC分类号： A61K8/73 ,  A23L29/271 ,  A23L33/10 ,  A23V2002/00 ,  A61Q19/00 ,  C12R1/645 ,  Y10S435/911 ,  A23V2250/5034 ,  A23V2200/318 ,  A23V2200/30

摘要： It is intended to utilize β-glucan produced by a bacterium belonging to Aureobasidium sp. From a bacterium belonging to Aureobasidium sp., a mutant with little pigment accumulation is constructed by a mutagenesis means of, for example, irradiating with ultraviolet light or treating with a mutagen. A culture obtained by culturing this mutant in a liquid culture medium is usable as a composition with a large β-glucan content without showing any intense dark green color caused by the accumulation of melanin-like pigments. This composition may be taken as such as a functional food having the physiologically active functions of the β-glucan-containing composition. Alternatively, it may be added to foods, drinks. food additives, cosmetics and so on.

摘要翻译： 旨在利用由属于Aureobasidium sp。的细菌产生的β-葡聚糖。 从属于Aureobasidium sp。的细菌，通过例如用紫外线照射或用诱变剂处理的诱变方法构建具有少量颜料积累的突变体。 通过在液体培养基中培养该突变体获得的培养物可用作具有大的β-葡聚糖含量的组合物，而不会由黑色素样颜料的积累引起强烈的深绿色。 该组合物可以作为具有含β-葡聚糖的组合物的生理活性功能的功能食品。 或者，它可以添加到食物，饮料中。 食品添加剂，化妆品等。

公开(公告)号：US20100068184A1

公开(公告)日：2010-03-18

申请号：US12513063

申请日：2007-10-22

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Koji Kubota

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Koji Kubota

IPC分类号： A61K35/66

CPC分类号： A61K36/062 ,  A61K9/0014 ,  A61K36/07 ,  C12N1/14 ,  C12R1/645

摘要： The present invention provides a living body healing, having an accelerating activity in the regeneration ability relating to the cure of damages of cells or tissues caused by toxicity of a drug or a wound in a living body, having high safety, and also not causing any side effect even administered for a long period of time. Problems are solved by a living body healing accelerator containing as an active constituent a mixture of a culture solution obtained after cultivation of a microorganism belonging to the Aureobasidium sp. and mycelia of the microorganism cultivated in the culture solution. The living body healing accelerator of the present invention is preferable used for reducing side effects of an anticancer drug, preferably used for acceleration of healing of a wound, and in addition, preferably used for acceleration of normalization of a blood glucose level and for alleviating a pathological state of leukemia.

摘要翻译： 本发明提供一种活体愈合，其具有与由活体内的药物或伤口的毒性引起的细胞或组织的毒性的固化相关的再生能力的加速活性，安全性高，也不引起任何 副作用甚至长时间施用。 通过生物体愈伤促进剂解决问题，所述促进剂含有作为活性成分的混合物，所述活性成分是培养属于所述Aureobasidium sp。 和在培养液中培养的微生物菌丝体。 本发明的活体愈合促进剂优选用于减少优选用于加速伤口愈合的抗癌药物的副作用，另外优选用于加速血糖水平的正常化，并且为了缓解 白血病的病理状态。

公开(公告)号：US20050272694A1

公开(公告)日：2005-12-08

申请号：US10531463

申请日：2004-03-04

申请人： Naoyuki Moriya ,  Yukiko Moriya ,  Kenji Suzuki

发明人： Naoyuki Moriya ,  Yukiko Moriya ,  Kenji Suzuki

IPC分类号： A61K8/00 ,  A61K8/72 ,  A61K8/73 ,  A61K8/96 ,  A61K31/716 ,  A61K35/744 ,  A61P1/10 ,  A61P17/16 ,  A61P37/04 ,  A61Q19/00 ,  A61K31/715 ,  C12P19/04

CPC分类号： A61K31/716 ,  A61K8/73 ,  A61K35/744 ,  A61Q19/00 ,  A61K2300/00

摘要： The present invention provides a composition containing β-glucan in which the physiologically active effects of β-1,3-1,6-glucan contained in a cultured composition of a bacterium belonging to the genus Aureobasidium sp. are further enhanced, and a constipation-relieving drug, preparation an immunopotentiator, and a skin moistening agent using the composition. A composition containing β-glucan, which contains a cultured composition containing β-1,3-1,6-glucan obtained by culturing a bacterium belonging to the genus Aureobasidium sp. and lactic acid bacterium cells, is obtained. This composition containing β-glucan is employed as an active ingredient of a constipation-relieving drug, an immunopotentiator, or a skin moistening agent. Aureobasidium pullulans M-1 (FERM BP-08615) is preferable as the bacterium belonging to the genus Aureobasidium sp. Moreover, Enterococcus faecalis is preferable as the lactic acid bacterium. It is still preferable that the lactic acid bacterium has been killed by heating. Furthermore, the content of the cultured composition in solid matters preferably ranges from 1 to 80% by mass in terms of β-1,3-1,6-glucan, while the content of the lactic acid bacterium cells preferably ranges from 4 to 95% by mass.

摘要翻译： 本发明提供含有β-葡聚糖的组合物，其中含有属于Aureobasidium属的细菌的培养组合物中的β-1,3-1,6-葡聚糖的生理活性作用。 进一步增强，便秘释放药物，制备免疫增强剂和使用该组合物的皮肤润湿剂。 含有β-葡聚糖的组合物，其含有通过培养属于Aureobasidium属的细菌得到的含有β-1,3-1,6-葡聚糖的培养组合物。 和乳酸菌细胞。 含有β-葡聚糖的组合物用作便秘释放药物，免疫增强剂或皮肤润湿剂的活性成分。 作为属于Aureobasidium属的细菌，优选优质芽孢杆菌M-1（FERM BP-08615） 此外，优选粪肠球菌作为乳酸菌。 乳酸菌还优选通过加热而杀死。 此外，固体成分的培养组合物的含量，以β-1,3-1,6-葡聚糖计，优选为1〜80质量％，乳酸菌细胞的含量优选为4〜95 质量％。