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公开(公告)号：US20210309629A1
公开(公告)日：2021-10-07
申请号：US17285443
申请日：2020-06-12
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
IPC分类号： C07D311/80 , C07C215/40 , C07C211/63 , C07D487/08 , C07D487/04 , C07D453/04
摘要： Disclosed are methods for separating, recovering, and purifying tetrahydrocannabinolic acid (THCA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in a selected C5-C7 hydrocarbon solvent, adding thereto a selected amine to thereby precipitate a THCA-amine salt therefrom, dissolving the recovered THCA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified THCA-amine salt therefrom. The recrystallized THCA-amine salt may be decarboxylated to form a mixture of Δ9-tetrahydrocannabinol (Δ9-THC) and amine. The Δ9-THC amine mixture may be acidified to separate the amine from Δ9-THC. The recovered Δ9-THC may be concentrated to produce a highly purified Δ9-THC. Also disclosed are THCA-amine salts produced with amines selected from groups of diamines, amino alcohols, and tertiary amines.
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公开(公告)号：US11208393B2
公开(公告)日：2021-12-28
申请号：US17285443
申请日：2020-06-12
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
IPC分类号： C07D311/80 , C07C215/40 , C07D453/04 , C07D487/08 , C07D487/04 , C07C211/63
摘要： Disclosed are methods for separating, recovering, and purifying tetrahydrocannabinolic acid (THCA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in a selected C5-C7 hydrocarbon solvent, adding thereto a selected amine to thereby precipitate a THCA-amine salt therefrom, dissolving the recovered THCA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified THCA-amine salt therefrom. The recrystallized THCA-amine salt may be decarboxylated to form a mixture of Δ9-tetrahydrocannabinol (Δ9-THC) and amine. The Δ9-THC amine mixture may be acidified to separate the amine from Δ9-THC. The recovered Δ9-THC may be concentrated to produce a highly purified Δ9-THC. Also disclosed are THCA-amine salts produced with amines selected from groups of diamines, amino alcohols, and tertiary amines.
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公开(公告)号：US20230089040A1
公开(公告)日：2023-03-23
申请号：US18046521
申请日：2022-10-14
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
IPC分类号： C07D311/80 , C07C211/63 , C07C215/40 , C07D453/04 , C07D487/04 , C07D487/08 , C07C51/43 , C07C65/19
摘要： Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.
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公开(公告)号：US11802118B2
公开(公告)日：2023-10-31
申请号：US17617341
申请日：2020-06-12
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
IPC分类号： C07D311/80 , C07C211/63 , C07C215/40 , C07D453/04 , C07D487/04 , C07D487/08 , C07C51/43 , C07C65/19
CPC分类号： C07D311/80 , C07C51/43 , C07C65/19 , C07C211/63 , C07C215/40 , C07D453/04 , C07D487/04 , C07D487/08 , C07D311/80 , C07B63/00 , C07D311/80 , C07B63/02
摘要： Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallizing a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. The recovered CBD may be concentrated to produce a highly purified CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.
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公开(公告)号：US20220220057A1
公开(公告)日：2022-07-14
申请号：US17617341
申请日：2020-06-12
发明人： Tony Durst , Jay Van Der Vlugt , Amanda Saikaley
摘要： Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallizing a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. The recovered CBD may be concentrated to produce a highly purified CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.
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