公开(公告)号：US20210309629A1

公开(公告)日：2021-10-07

申请号：US17285443

申请日：2020-06-12

Applicant: Nectar Health Sciences Inc.

Inventor： Tony Durst ,  Jay Van Der Vlugt ,  Amanda Saikaley

IPC: C07D311/80 ,  C07C215/40 ,  C07C211/63 ,  C07D487/08 ,  C07D487/04 ,  C07D453/04

Abstract: Disclosed are methods for separating, recovering, and purifying tetrahydrocannabinolic acid (THCA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in a selected C5-C7 hydrocarbon solvent, adding thereto a selected amine to thereby precipitate a THCA-amine salt therefrom, dissolving the recovered THCA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified THCA-amine salt therefrom. The recrystallized THCA-amine salt may be decarboxylated to form a mixture of Δ9-tetrahydrocannabinol (Δ9-THC) and amine. The Δ9-THC amine mixture may be acidified to separate the amine from Δ9-THC. The recovered Δ9-THC may be concentrated to produce a highly purified Δ9-THC. Also disclosed are THCA-amine salts produced with amines selected from groups of diamines, amino alcohols, and tertiary amines.

公开(公告)号：US20240190834A1

公开(公告)日：2024-06-13

申请号：US18256033

申请日：2021-12-06

Applicant: Nectar Health Sciences Inc.

Inventor： Jay Van Der Vlugt ,  Tony Durst

IPC: C07D311/80 ,  C07C37/84 ,  C07C211/62 ,  C07C211/63 ,  C07D211/12 ,  C07D213/74 ,  C07D453/02 ,  C07D487/04

CPC classification number: C07D311/80 ,  C07C37/84 ,  C07C211/62 ,  C07C211/63 ,  C07D211/12 ,  C07D213/74 ,  C07D453/02 ,  C07D487/04

Abstract: Disclosed are methods for separating, recovering, and purifying CBGA, CBDVA, THCVA, CBCVA, and CBCA from dewatered and desolventized crude complex extracts or mixtures of metabolites, cannabinoids, and Cannabis phytochemicals. The methods comprise solubilizing the extracts or mixtures of cannabinoids in a selected solvent, adding a selected amine to precipitate a CBGA-amine or CBDVA-amine or THCVA-amine or CBCVA-amine or CBCA-amine salt therefrom, dissolving the recovered amine salt in a selected solvent, and adding a selected antisolvent to recrystallize a purified amine salt therefrom. The recrystallized amine salt may be decarboxylated to form a mixture of CBG or CBDV or THCV or CBCV or CBC and amine. The cannabinoid and amine mixture may be acidified to separate the amine from CBG or CBDV or THCV or CBCV or CBC. The recovered CBG or CBDV or THCV or CBCV or CBC may then be concentrated.

公开(公告)号：US11208393B2

公开(公告)日：2021-12-28

申请号：US17285443

申请日：2020-06-12

Applicant: Nectar Health Sciences Inc.

Inventor： Tony Durst ,  Jay Van Der Vlugt ,  Amanda Saikaley

IPC: C07D311/80 ,  C07C215/40 ,  C07D453/04 ,  C07D487/08 ,  C07D487/04 ,  C07C211/63

Abstract: Disclosed are methods for separating, recovering, and purifying tetrahydrocannabinolic acid (THCA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in a selected C5-C7 hydrocarbon solvent, adding thereto a selected amine to thereby precipitate a THCA-amine salt therefrom, dissolving the recovered THCA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified THCA-amine salt therefrom. The recrystallized THCA-amine salt may be decarboxylated to form a mixture of Δ9-tetrahydrocannabinol (Δ9-THC) and amine. The Δ9-THC amine mixture may be acidified to separate the amine from Δ9-THC. The recovered Δ9-THC may be concentrated to produce a highly purified Δ9-THC. Also disclosed are THCA-amine salts produced with amines selected from groups of diamines, amino alcohols, and tertiary amines.

公开(公告)号：US11802118B2

公开(公告)日：2023-10-31

申请号：US17617341

申请日：2020-06-12

Applicant: Nectar Health Sciences Inc.

Inventor： Tony Durst ,  Jay Van Der Vlugt ,  Amanda Saikaley

IPC: C07D311/80 ,  C07C211/63 ,  C07C215/40 ,  C07D453/04 ,  C07D487/04 ,  C07D487/08 ,  C07C51/43 ,  C07C65/19

CPC classification number: C07D311/80 ,  C07C51/43 ,  C07C65/19 ,  C07C211/63 ,  C07C215/40 ,  C07D453/04 ,  C07D487/04 ,  C07D487/08 ,  C07D311/80 ,  C07B63/00 ,  C07D311/80 ,  C07B63/02

Abstract: Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallizing a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. The recovered CBD may be concentrated to produce a highly purified CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.

公开(公告)号：US20220220057A1

公开(公告)日：2022-07-14

申请号：US17617341

申请日：2020-06-12

Applicant: Nectar Health Sciences Inc.

Inventor： Tony Durst ,  Jay Van Der Vlugt ,  Amanda Saikaley

IPC: C07C51/43 ,  C07C65/19

Abstract: Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallizing a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. The recovered CBD may be concentrated to produce a highly purified CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.

公开(公告)号：US20230089040A1

公开(公告)日：2023-03-23

申请号：US18046521

申请日：2022-10-14

Applicant: Nectar Health Sciences Inc.

Inventor： Tony Durst ,  Jay Van Der Vlugt ,  Amanda Saikaley

IPC: C07D311/80 ,  C07C211/63 ,  C07C215/40 ,  C07D453/04 ,  C07D487/04 ,  C07D487/08 ,  C07C51/43 ,  C07C65/19

Abstract: Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.