公开(公告)号：US20240166735A1

公开(公告)日：2024-05-23

申请号：US18350287

申请日：2023-07-11

Applicant: Neuracle Science Co., Ltd.

Inventor： Jae Young SEONG ,  Jong Ik HWANG ,  Woong SUN ,  Eun Bee CHO ,  Won-Ki KIM

IPC: C07K16/24 ,  A61K38/17 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/577 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/24 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/4701 ,  C07K14/4702 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/577 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/76 ,  C12N2310/11 ,  C12N2310/141 ,  C12Q2600/156 ,  G01N2333/47

Abstract: The present invention relates to the pharmaceutical use of FAM19A5 involved in regulating gliogenesis, and more specifically, to the use of FAM19A5 in the prevention, diagnosis, or treatment of central nervous system injuries, degenerative brain diseases, or central nervous system diseases, FAM19A5 being spread in the neural stem cells in vertebrates and regulating gliogenesis.

公开(公告)号：US20200270337A1

公开(公告)日：2020-08-27

申请号：US16807902

申请日：2020-03-03

Applicant: Neuracle Science Co., Ltd.

Inventor： Jae Young SEONG ,  Jong Ik HWANG ,  Woong SUN ,  Eun Bee CHO ,  Won-Ki KIM

IPC: C07K16/24 ,  C07K14/47 ,  C12Q1/6886 ,  A61K38/17 ,  A61K48/00 ,  C07K16/18 ,  C12N15/113 ,  G01N33/577 ,  G01N33/68

Abstract: The present invention relates to the pharmaceutical use of FAM19A5 involved in regulating gliogenesis, and more specifically, to the use of FAM19A5 in the prevention, diagnosis, or treatment of central nervous system injuries, degenerative brain diseases, or central nervous system diseases, FAM19A5 being spread in the neural stem cells in vertebrates and regulating gliogenesis.

公开(公告)号：US20190300599A1

公开(公告)日：2019-10-03

申请号：US16348058

申请日：2017-11-07

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol KIM ,  Jae Young SEONG ,  Jong Ik HWANG ,  Eun Bee CHO ,  Junho CHUNG ,  Junyeong JIN ,  Tae Young YUNE ,  Jee Youn LEE

IPC: C07K16/18 ,  G01N33/563

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.

公开(公告)号：US20220372122A1

公开(公告)日：2022-11-24

申请号：US17723149

申请日：2022-04-18

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol KIM ,  Jae Young SEONG ,  Jong Ik HWANG ,  Eun Bee CHO ,  Junho CHUNG ,  Junyeong JIN ,  Tae Young YUNE ,  Jee Youn LEE

IPC: C07K16/18 ,  G01N33/563 ,  C07K7/00

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.