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公开(公告)号:US20120165321A1
公开(公告)日:2012-06-28
申请号:US13411887
申请日:2012-03-05
申请人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerrard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
发明人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerrard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
IPC分类号: A61K31/4709 , C07D413/14 , A61K31/5377 , A61K31/496 , C07D471/04 , C07D498/04 , A61K31/5383 , C07D417/14 , A61K31/549 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P37/08 , A61P11/06 , A61P1/18 , A61P13/12 , A61P7/02 , A61P35/00 , A61P15/08 , A61P37/06 , A61P11/00 , A61P17/06 , A61P19/04 , A61P1/00 , A61P25/14 , A61P25/00 , A61P9/10 , A61P9/08 , A61P21/00 , A61P35/04 , A61P31/04 , A61P31/12 , A61P35/02 , C07D401/14
CPC分类号: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
摘要翻译: 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号:US20080300239A1
公开(公告)日:2008-12-04
申请号:US12121891
申请日:2008-05-16
申请人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerrard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
发明人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerrard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
IPC分类号: A61K31/4709 , C07D401/14 , C07D413/14 , A61K31/5383 , A61P35/00 , A61K31/549 , A61K31/5377 , C07D285/24
CPC分类号: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
摘要翻译: 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号:US08404837B2
公开(公告)日:2013-03-26
申请号:US12600745
申请日:2008-05-16
申请人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
发明人: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
IPC分类号: C07D401/14 , C07D413/14 , C07D498/04
CPC分类号: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
摘要翻译: 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号:US07495102B2
公开(公告)日:2009-02-24
申请号:US11855183
申请日:2007-09-14
申请人: Martha A. Sarpong , Nicholas D. Adams , Jeffrey Michael Axten , Amita M. Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Allen Newlander , Cynthia A. Parrish , Jerry Leroy Adams , Domingos J. Silva , Jun Tang
发明人: Martha A. Sarpong , Nicholas D. Adams , Jeffrey Michael Axten , Amita M. Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Allen Newlander , Cynthia A. Parrish , Jerry Leroy Adams , Domingos J. Silva , Jun Tang
IPC分类号: C07D453/02
CPC分类号: C07D471/04
摘要: The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
摘要翻译: 本发明涉及由式(I)表示的化合物及其药学上可接受的盐。 本发明的化合物抑制Aurora激酶,使其特别适用于治疗许多疾病,包括实体瘤癌症和血液癌症。
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公开(公告)号:US20100234386A1
公开(公告)日:2010-09-16
申请号:US12599544
申请日:2008-05-08
申请人: Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
发明人: Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
IPC分类号: A61K31/498 , C07D401/02 , A61P29/00 , A61P9/00 , A61P25/00 , A61P11/06 , A61P13/12 , A61P35/00 , A61P15/00
CPC分类号: C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/14
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
摘要翻译: 发明的是使用喹喔啉衍生物抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用喹喔啉衍生物的移植排斥和肺部损伤。
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