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公开(公告)号：US20210139585A1
公开(公告)日：2021-05-13
申请号：US16877878
申请日：2020-05-19
Applicant: Novartis AG
Inventor： Brian Granda , Amy Rayo , Connie Hong , Dattananda Chelur , Haihui Lu , Regis Cebe , Sunyoung Jang
Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.
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公开(公告)号：US20250000973A1
公开(公告)日：2025-01-02
申请号：US18684417
申请日：2022-08-19
Applicant: Novartis AG
Inventor： Michael Bardroff , Regis Cebe , Brian Walter Granda , Shyamali Jayashankar , Sandeep Tharian Koshy , Sandra Miller , Andrew Patrick Price , Amy Rayo , Darko Skegro , Louise Mary Treanor , Jennifer Yang
IPC: A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/0783
Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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公开(公告)号：US12221481B2
公开(公告)日：2025-02-11
申请号：US16877878
申请日：2020-05-19
Applicant: Novartis AG
Inventor： Brian Granda , Amy Rayo , Connie Hong , Dattananda Chelur , Haihui Lu , Regis Cebe , Sunyoung Jang
Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.
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公开(公告)号：US20230302155A1
公开(公告)日：2023-09-28
申请号：US18022058
申请日：2021-08-20
Applicant: Novartis AG
Inventor： Sandeep Tharian Koshy , Glenn Dranoff , Maria Anna Sofia Broggi , Chris Bridgeman , Stephen Michael Canham , Yoel Melles , Regis Cebe , Brian Walter Granda , Louise Mary Treanor , Shyamali Jayashankar , Jennifer Yang , Amy Rayo , Andrew Patrick Price , Darko Skegro , Justine Guyot , Tushar Dattu Apsunde , Cameron Chuck-munn Lee , Michael Bardroff , Sandra Miller
IPC: A61K47/69 , A61K9/06 , A61K38/18 , C12N15/86 , A61K38/20 , A61K38/17 , C07K14/705 , C07K14/725 , C07K16/28 , A61K39/395 , A61K39/00 , A61K31/4745
CPC classification number: A61K47/6927 , A61K9/06 , A61K38/1858 , C12N15/86 , A61K38/2086 , A61K38/2046 , A61K47/6901 , A61K38/1774 , C07K14/70517 , C07K14/70578 , A61K38/177 , C07K14/70521 , C07K14/7051 , C07K16/2806 , C07K16/2818 , C07K16/2809 , A61K39/3955 , A61K39/4631 , A61K31/4745 , C12N2740/15043 , C12N2740/15071 , A61K2039/505 , C07K2319/33 , C07K2319/03 , A61K2239/21 , C07K2319/02 , A61K2239/22 , C07K2317/31 , A61K2239/29 , C07K2317/55 , C07K2317/622 , C07K2317/524 , C07K2317/526 , C07K2317/522 , A61K2039/545 , A61K2239/38 , A61K2239/13 , C07K2317/75
Abstract: Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent.
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