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1.发明申请公开(公告)号：US20220387486A1
公开(公告)日：2022-12-08
申请号：US17246351
申请日：2021-04-30
Inventor： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Walter Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Patricia Pinto Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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公开(公告)号：US20230302155A1
公开(公告)日：2023-09-28
申请号：US18022058
申请日：2021-08-20
Applicant: Novartis AG
Inventor： Sandeep Tharian Koshy , Glenn Dranoff , Maria Anna Sofia Broggi , Chris Bridgeman , Stephen Michael Canham , Yoel Melles , Regis Cebe , Brian Walter Granda , Louise Mary Treanor , Shyamali Jayashankar , Jennifer Yang , Amy Rayo , Andrew Patrick Price , Darko Skegro , Justine Guyot , Tushar Dattu Apsunde , Cameron Chuck-munn Lee , Michael Bardroff , Sandra Miller
IPC: A61K47/69 , A61K9/06 , A61K38/18 , C12N15/86 , A61K38/20 , A61K38/17 , C07K14/705 , C07K14/725 , C07K16/28 , A61K39/395 , A61K39/00 , A61K31/4745
CPC classification number: A61K47/6927 , A61K9/06 , A61K38/1858 , C12N15/86 , A61K38/2086 , A61K38/2046 , A61K47/6901 , A61K38/1774 , C07K14/70517 , C07K14/70578 , A61K38/177 , C07K14/70521 , C07K14/7051 , C07K16/2806 , C07K16/2818 , C07K16/2809 , A61K39/3955 , A61K39/4631 , A61K31/4745 , C12N2740/15043 , C12N2740/15071 , A61K2039/505 , C07K2319/33 , C07K2319/03 , A61K2239/21 , C07K2319/02 , A61K2239/22 , C07K2317/31 , A61K2239/29 , C07K2317/55 , C07K2317/622 , C07K2317/524 , C07K2317/526 , C07K2317/522 , A61K2039/545 , A61K2239/38 , A61K2239/13 , C07K2317/75
Abstract: Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent.
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3.发明授权公开(公告)号：US11026976B2
公开(公告)日：2021-06-08
申请号：US16664223
申请日：2019-10-25
Inventor： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Walter Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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Patent Agency Ranking
公开(公告)号：US20240252538A1
公开(公告)日：2024-08-01
申请号：US18529915
申请日：2023-12-05
Inventor： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Walter Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Patricia Pinto Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
CPC classification number: A61K35/17 , A61K38/1774 , A61P35/00 , C07K16/2803 , C07K16/2887 , C07K16/2896 , C12N15/85 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/03 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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公开(公告)号：US20220396631A1
公开(公告)日：2022-12-15
申请号：US17595637
申请日：2020-05-19
Applicant: Lu HUANG , Brian GRANDA , John BLANKENSHIP , Aida ABUJOUB , Tony FLEMING , Haihui LU , Connie HONG , Brian HOLMBERG , Novartis AG
Inventor： Brian Walter Granda , John Blankenship , Aida Abujoub , Tony Fleming , Lu Huang , Connie Hong , Brian Holmberg , Haihui Lu
IPC: C07K16/28
Abstract: The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.
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公开(公告)号：US20210220404A1
公开(公告)日：2021-07-22
申请号：US17104983
申请日：2020-11-25
Applicant: Michael R. Greene , Novartis AG
Inventor： Aida Abujoub , John Blankenship , Attilio Bondanza , Jennifer Brogdon , Dexiu Bu , Serena De Vita , Glenn Dranoff , Boris Engels , Tony Fleming , Brian Walter Granda , Michael R. Greene , Carla Patricia Guimaraes , Anniesha Hack , Brian Holmberg , Connie Hong , Lu Huang , Olja Kodrasi , Joni Waiee Lam , Hyungwook Lim , Elizabeth Dorothy Pratico , Andrew Price , Akash Sohoni , Andrew Marc Stein , Louise Treanor , Chonghui Zhang , Xu Zhu
IPC: A61K35/17 , C07K16/28 , A61P35/00 , A61K45/06 , A61K39/395 , C07K14/705 , A61K38/17 , C12N5/0783 , C07K14/725
Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.
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公开(公告)号：US20250000973A1
公开(公告)日：2025-01-02
申请号：US18684417
申请日：2022-08-19
Applicant: Novartis AG
Inventor： Michael Bardroff , Regis Cebe , Brian Walter Granda , Shyamali Jayashankar , Sandeep Tharian Koshy , Sandra Miller , Andrew Patrick Price , Amy Rayo , Darko Skegro , Louise Mary Treanor , Jennifer Yang
IPC: A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/0783
Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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公开(公告)号：US11872249B2
公开(公告)日：2024-01-16
申请号：US17246351
申请日：2021-04-30
Inventor： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Walter Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Patricia Pinto Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
CPC classification number: A61K35/17 , A61K38/1774 , A61P35/00 , C07K16/2803 , C07K16/2887 , C07K16/2896 , C12N15/85 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/03 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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