公开(公告)号：US20250000973A1

公开(公告)日：2025-01-02

申请号：US18684417

申请日：2022-08-19

Applicant: Novartis AG

Inventor： Michael Bardroff ,  Regis Cebe ,  Brian Walter Granda ,  Shyamali Jayashankar ,  Sandeep Tharian Koshy ,  Sandra Miller ,  Andrew Patrick Price ,  Amy Rayo ,  Darko Skegro ,  Louise Mary Treanor ,  Jennifer Yang

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.

公开(公告)号：US20230302155A1

公开(公告)日：2023-09-28

申请号：US18022058

申请日：2021-08-20

Applicant: Novartis AG

Inventor： Sandeep Tharian Koshy ,  Glenn Dranoff ,  Maria Anna Sofia Broggi ,  Chris Bridgeman ,  Stephen Michael Canham ,  Yoel Melles ,  Regis Cebe ,  Brian Walter Granda ,  Louise Mary Treanor ,  Shyamali Jayashankar ,  Jennifer Yang ,  Amy Rayo ,  Andrew Patrick Price ,  Darko Skegro ,  Justine Guyot ,  Tushar Dattu Apsunde ,  Cameron Chuck-munn Lee ,  Michael Bardroff ,  Sandra Miller

IPC: A61K47/69 ,  A61K9/06 ,  A61K38/18 ,  C12N15/86 ,  A61K38/20 ,  A61K38/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K31/4745

CPC classification number: A61K47/6927 ,  A61K9/06 ,  A61K38/1858 ,  C12N15/86 ,  A61K38/2086 ,  A61K38/2046 ,  A61K47/6901 ,  A61K38/1774 ,  C07K14/70517 ,  C07K14/70578 ,  A61K38/177 ,  C07K14/70521 ,  C07K14/7051 ,  C07K16/2806 ,  C07K16/2818 ,  C07K16/2809 ,  A61K39/3955 ,  A61K39/4631 ,  A61K31/4745 ,  C12N2740/15043 ,  C12N2740/15071 ,  A61K2039/505 ,  C07K2319/33 ,  C07K2319/03 ,  A61K2239/21 ,  C07K2319/02 ,  A61K2239/22 ,  C07K2317/31 ,  A61K2239/29 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/522 ,  A61K2039/545 ,  A61K2239/38 ,  A61K2239/13 ,  C07K2317/75

Abstract: Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent.