公开(公告)号：US12171839B2

公开(公告)日：2024-12-24

申请号：US17833077

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Anthony Edward Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno ,  Ben Wen

IPC: C07K16/00 ,  A61K38/07 ,  A61K38/12 ,  A61K47/68 ,  C07K16/28 ,  C07K16/46

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20250064964A1

公开(公告)日：2025-02-27

申请号：US18937914

申请日：2024-11-05

Applicant: Novartis AG

Inventor： Anthony Edward Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno ,  Ben Wen

IPC: A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoetic stem cells in a patient in need thereof.

公开(公告)号：US11357864B2

公开(公告)日：2022-06-14

申请号：US16470897

申请日：2017-12-19

Applicant: NOVARTIS AG

Inventor： Ben Wen ,  Anthony E. Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.