公开(公告)号：US20250064964A1

公开(公告)日：2025-02-27

申请号：US18937914

申请日：2024-11-05

Applicant: Novartis AG

Inventor： Anthony Edward Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno ,  Ben Wen

IPC: A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoetic stem cells in a patient in need thereof.

公开(公告)号：US11357864B2

公开(公告)日：2022-06-14

申请号：US16470897

申请日：2017-12-19

Applicant: NOVARTIS AG

Inventor： Ben Wen ,  Anthony E. Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US11833215B2

公开(公告)日：2023-12-05

申请号：US16893359

申请日：2020-06-04

Applicant: Novartis AG

Inventor： Tinya Abrams ,  Steven Bruce Cohen ,  Dylan Daniel ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Thomas Huber ,  William Mallet ,  Matthew John Meyer ,  Weijia Ou ,  Siew Ho Schleyer ,  Kathrin Ulrike Tissot-Daguette

IPC: C07K16/00 ,  A61K39/00 ,  A61K47/68 ,  C07K16/28 ,  A61K51/10 ,  A61K49/00 ,  A61P35/02 ,  A61K39/395

CPC classification number: A61K47/6803 ,  A61K39/39558 ,  A61K47/6849 ,  A61K49/00 ,  A61K51/103 ,  A61K51/1093 ,  A61P35/02 ,  C07K16/2803 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

公开(公告)号：US10117953B2

公开(公告)日：2018-11-06

申请号：US15284444

申请日：2016-10-03

Applicant: Novartis AG

Inventor： Tinya Abrams ,  Steven Bruce Cohen ,  Christie P. Fanton ,  Thomas Huber ,  Kathy Miller ,  Siew Ho Schleyer ,  Kathrin Ulrike Tissot-Daguette ,  Catrin Finner

IPC: A61K47/48 ,  A61K47/68 ,  A61K45/06 ,  C07K16/28 ,  A61K31/537 ,  A61K47/12 ,  A61K47/26 ,  A61K9/19 ,  A61K9/00 ,  A61K49/00 ,  A61K51/10 ,  C07K16/32 ,  A61K39/00

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

公开(公告)号：US12171839B2

公开(公告)日：2024-12-24

申请号：US17833077

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Anthony Edward Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno ,  Ben Wen

IPC: C07K16/00 ,  A61K38/07 ,  A61K38/12 ,  A61K47/68 ,  C07K16/28 ,  C07K16/46

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US10786578B2

公开(公告)日：2020-09-29

申请号：US15329818

申请日：2015-07-27

Applicant: Novartis AG

Inventor： Tinya Abrams ,  Steven Bruce Cohen ,  Dylan Daniel ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Thomas Huber ,  William Mallet ,  Matthew John Meyer ,  Weijia Ou ,  Siew Ho Schleyer ,  Kathrin Ulrike Tissot-Daguette

IPC: A61K39/00 ,  A61K47/68 ,  C07K16/28 ,  A61K51/10 ,  A61K49/00 ,  A61P35/02 ,  A61K39/395

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.