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    CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS
    1.
    发明申请
    CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS 有权

    公开(公告)号：US20210093733A1

    公开(公告)日：2021-04-01

    申请号：US17006881

    申请日：2020-08-30

    申请人： OBI Pharma, Inc.

    发明人： Michael Nientse CHANG ,  Ming-Tain LAI ,  Jiann-Shiun LAI ,  Yi-Chien TSAI ,  I-Ju CHEN ,  Wan-Fen LI ,  Kai-Chuan CHEN ,  Teng-Yi HUANG ,  Shu-Yi LIN

    IPC分类号： A61K47/68 ,  C07K16/18 ,  A61K45/06 ,  A61P35/00

    摘要： Antibody drug conjugates (ADC's) comprising a drug moiety/payload conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

    HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
    4.
    发明申请
    HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 有权

    公开(公告)号：US20210284719A1

    公开(公告)日：2021-09-16

    申请号：US16321417

    申请日：2017-07-31

    申请人： OBI PHARMA, INC.

    发明人： Cheng-Der Tony YU ,  Woan Eng CHAN ,  Shu-Yu LEE ,  Jiann-Shiun LAI ,  I-Ju CHEN

    IPC分类号： C07K16/18 ,  G01N33/574 ,  A61K47/68 ,  A61K49/16 ,  A61K45/06

    摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to Globo H, stage-specific embryonic antigen 3 (SSEA-3) and stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

    ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
    5.
    发明申请
    ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 有权

    公开(公告)号：US20210228732A1

    公开(公告)日：2021-07-29

    申请号：US17160282

    申请日：2021-01-27

    申请人： OBI Pharma, Inc.

    发明人： Cheng-Der Tony YU ,  Jiann-Shiun LAI ,  I-Ju CHEN ,  Chiu-Chun LIN

    IPC分类号： A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  A61K31/4025 ,  A61K39/395 ,  C07K16/18 ,  C07K16/30

    摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnositcs. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and/or brain tumor.

    ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
    8.
    发明申请
    ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开

    公开(公告)号：US20180339061A1

    公开(公告)日：2018-11-29

    申请号：US15996192

    申请日：2018-06-01

    申请人： OBI Pharma, Inc.

    发明人： Cheng-Der Tony YU ,  Jiann-Shiun LAI ,  I-Ju CHEN ,  Chiu-Chun LIN

    IPC分类号： A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K31/4025

    摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and/or brain tumor.