公开(公告)号：US20240084040A1

公开(公告)日：2024-03-14

申请号：US18264563

申请日：2022-02-09

申请人： OBI PHARMA, INC.

发明人： Jiann-Shiun LAI ,  Hui-Wen CHANG ,  Yin-Chieh KUO ,  Chi-Sheng HSIA ,  Woan Eng CHAN ,  Ming-Tain LAI

IPC分类号： C07K16/46 ,  A61P35/00

CPC分类号： C07K16/468 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565

摘要： The present invention provides antibody or the antigen-binding portion thereof bind to carbohydrate antigen, such as Globo series antigens (e.g. Globo H, SSEA-4 or SSEA-3). Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.

公开(公告)号：US20210284719A1

公开(公告)日：2021-09-16

申请号：US16321417

申请日：2017-07-31

申请人： OBI PHARMA, INC.

发明人： Cheng-Der Tony YU ,  Woan Eng CHAN ,  Shu-Yu LEE ,  Jiann-Shiun LAI ,  I-Ju CHEN

IPC分类号： C07K16/18 ,  G01N33/574 ,  A61K47/68 ,  A61K49/16 ,  A61K45/06

摘要： Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to Globo H, stage-specific embryonic antigen 3 (SSEA-3) and stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.