公开(公告)号：US20240084040A1

公开(公告)日：2024-03-14

申请号：US18264563

申请日：2022-02-09

申请人： OBI PHARMA, INC.

发明人： Jiann-Shiun LAI ,  Hui-Wen CHANG ,  Yin-Chieh KUO ,  Chi-Sheng HSIA ,  Woan Eng CHAN ,  Ming-Tain LAI

IPC分类号： C07K16/46 ,  A61P35/00

CPC分类号： C07K16/468 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565

摘要： The present invention provides antibody or the antigen-binding portion thereof bind to carbohydrate antigen, such as Globo series antigens (e.g. Globo H, SSEA-4 or SSEA-3). Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.