公开(公告)号：US20240252612A1

公开(公告)日：2024-08-01

申请号：US18533167

申请日：2023-12-07

Applicant: PFIZER INC.

Inventor： Fanyu Meng ,  Lynn Marie Phelan ,  Pirada Suphaphiphat Allen ,  Nicholas Luksha ,  Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Jayesh Vijay Sonje ,  Serguei Tchessalov ,  Advait Vijay Badkar ,  Michael David Bruchsaler ,  Wouter Joris Knapen ,  Parag Kolhe ,  Marjoh Anne Nauta ,  Naomi Sasha Ramesar ,  Vincent Jurgen L. Van Deyck ,  Bert Van Meervenne ,  Thijs Vanslembrouck ,  Sarah Elizabeth Weiser

IPC: A61K39/145 ,  A61K9/00 ,  A61K9/14 ,  A61K9/19 ,  A61K39/00 ,  A61K47/26

CPC classification number: A61K39/145 ,  A61K9/0019 ,  A61K9/146 ,  A61K9/19 ,  A61K47/26 ,  A61K2039/55555 ,  A61K2039/575

Abstract: The present disclosure relates to compositions comprising RNA molecules encoding an antigen derived from influenza, wherein the RNA may be formulated in a lipid nanoparticle (LNP), and wherein the composition further includes a polypeptide antigen derived from respiratory syncytial virus (RSV) and/or RNA molecules encoding an antigen derived from RSV, wherein the RSV RNA may be may be formulated in an LNP. The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the prevention of influenza and RSV infection-induced illness.