公开(公告)号：US06764472B1

公开(公告)日：2004-07-20

申请号：US09481298

申请日：2000-01-11

申请人： Paul F. Burke ,  Kenneth A. Fine

发明人： Paul F. Burke ,  Kenneth A. Fine

IPC分类号： A61M3100

CPC分类号： A61M5/14276 ,  A61M5/14586 ,  A61M5/14593 ,  A61M2209/045

摘要： An implantable infusion device includes a lightweight, inert housing which contains an infusate for administration to a patient, and an enclosed, gas-impermeable variable volume chamber which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery. The lightweight housing may include integrally formed needle stops and suture fastening loops.

摘要翻译： 植入式输注装置包括轻量级的惰性壳体，其包含用于给患者施用的输液器，以及包含压力源（例如推进剂，机械弹簧等）的封闭的气体不可渗透的可变体积腔室。 可变体积室可以是刚性可膨胀波纹管结构或不可拉伸柔性袋的形式，并且附接到壳体，以便不妨碍用于引入输注物的入口。 响应于可变体积腔室相对于壳体中的输注体积的膨胀，通过导管从装置输送输注液。 提供单独的推注注射口，其允许输注物被直接导入导管并且覆盖受控的压力驱动输送。 轻便的外壳可以包括一体形成的针止动件和缝线紧固环。

公开(公告)号：US06409698B1

公开(公告)日：2002-06-25

申请号：US09723057

申请日：2000-11-27

申请人： John N. Robinson ,  Paul F. Burke ,  Kenneth A. Fine

发明人： John N. Robinson ,  Paul F. Burke ,  Kenneth A. Fine

IPC分类号： D57

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M31/002 ,  A61M39/0208 ,  A61M2005/14513 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61N1/30

摘要： An electrodiffusion pump includes a housing having an inlet, drug reservoir, and outlet. A diffusion membrane is disposed between the reservoir and outlet for diffusing the drug outwardly therethrough. Internal and external electrodes are disposed on opposite sides of the membrane. The electrodes are porous, and the external electrode is additionally perforate to expose a portion of the membrane at the outlet. The electrodes are electrically powered for driving drug ions through the membrane under electrophoresis to complement diffusion thereof.

摘要翻译： 电扩散泵包括具有入口，药物储存器和出口的壳体。 扩散膜设置在储存器和出口之间，用于将药物向外扩散通过。 内部和外部电极设置在膜的相对侧上。 电极是多孔的，并且外部电极另外穿孔以在出口处暴露膜的一部分。 电极被电力驱动，以在电泳下驱动药物离子通过膜以补充其扩散。

公开(公告)号：US07108686B2

公开(公告)日：2006-09-19

申请号：US10169821

申请日：2001-01-11

申请人： Paul Burke ,  Kenneth A. Fine

发明人： Paul Burke ,  Kenneth A. Fine

IPC分类号： A61K9/22 ,  A61M37/00 ,  A61M31/00

CPC分类号： A61M5/14276 ,  A61M5/14586 ,  A61M5/14593 ,  A61M2209/045

摘要： An implantable infusion device (10) includes a lightweight, inert housing (12) which contains an infusate (18) for administration to a patient, and an enclosed, gas-impermeable variable volume chamber (30) which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. A recharging fluid flow path (31) is provided adjacent to where the variable volume chamber is attached to the housing. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port (38) is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery. The lightweight housing may include integrally formed needle stops (32 and 34) and suture fastening loops (36).

摘要翻译： 植入式输注装置（10）包括轻量级惰性壳体（12），其容纳用于向患者施用的输液管（18），以及封闭的气体不可渗透的可变体积腔室（30），其包含压力源，例如 推进剂，机械弹簧等。 可变体积室可以是刚性可膨胀波纹管结构或不可拉伸柔性袋的形式，并且附接到壳体，以便不妨碍用于引入输注物的入口。 在可变容积室附接到壳体的附近设置充液流体流动路径（31）。 响应于可变体积腔室相对于壳体中的输注体积的膨胀，通过导管从装置输送输注液。 提供单独的推注注射口（38），其允许将输注物直接安全地导入导管中并且覆盖受控的压力驱动输送。 轻便的外壳可以包括一体形成的针止动件（32和34）和缝线紧固环（36）。