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1.Method for introducing human immunodeficiency virus nucleotide sequences into a cell utilizing modified vaccinia virus Ankara (MVA) recombinants comprising HIV genes inserted into one or more intergenic regions (IGRs) 有权
标题翻译: 使用修饰的痘苗病毒将人免疫缺陷病毒核苷酸序列引入细胞的方法将包含插入到一个或多个基因间区域(IGR)中的HIV基因的安卡拉(MVA)重组体公开(公告)号:US08198088B2
公开(公告)日:2012-06-12
申请号:US13221952
申请日:2011-08-31
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: C12N15/86 , C12N15/00 , A61K39/12 , A61K39/21 , A61K39/275
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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公开(公告)号:US20120015423A1
公开(公告)日:2012-01-19
申请号:US13221108
申请日:2011-08-30
申请人: Paul HOWLEY , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul HOWLEY , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: C12N7/01
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
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3.INTERGENIC REGIONS AS NOVEL SITES FOR INSERTION OF HIV DNA SEQUENCES IN THE GENOME OF MODIFIED VACCINIA VIRUS ANKARA 有权
标题翻译: 作为在修饰的疫苗病毒ANKARA基因组中插入HIV DNA序列的新的基因座公开(公告)号:US20120014922A1
公开(公告)日:2012-01-19
申请号:US13222020
申请日:2011-08-31
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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4.Recombinant modified vaccinia virus ankara (MVA) comprising human immunodeficiency virus (HIV) genes inserted into one or more intergenic regions (IGRs) 有权
标题翻译: 包含插入到一个或多个基因间区域(IGR)中的人免疫缺陷病毒(HIV)基因的重组修饰的痘苗病毒安卡拉(MVA)公开(公告)号:US08029800B2
公开(公告)日:2011-10-04
申请号:US12393861
申请日:2009-02-26
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: A61K39/12 , A61K39/21 , A61K39/275
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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5.Recombinant modified vaccinia ankara (MVA) virus containing heterologous DNA inserts encoding human immunodeficiency virus (HIV) antigens inserted into one or more intergenic regions (IGRs) 有权
标题翻译: 含有插入到一个或多个基因间区域(IGR)中的编码人免疫缺陷病毒(HIV)抗原的异源DNA插入片段的重组修饰的牛痘安卡拉(MVA)病毒公开(公告)号:US08309098B2
公开(公告)日:2012-11-13
申请号:US13222020
申请日:2011-08-31
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: A61K39/21 , A61K39/275
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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6.Methods for inducing an immune response in a host comprising administering modified vaccinia virus ankara (MVA) recombinants comprising human immunodeficiency virus (HIV) genes inserted into one or more intergenic regions (IGRs) 有权
标题翻译: 在宿主中诱导免疫应答的方法,包括施用包含插入到一个或多个基因间区域(IGR)中的人免疫缺陷病毒(HIV)基因的修饰的痘苗病毒安卡拉(MVA)重组体,公开(公告)号:US08021669B2
公开(公告)日:2011-09-20
申请号:US12393840
申请日:2009-02-26
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: A61K39/12 , A61K39/21 , A61K39/275
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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7.Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of modified vaccinia virus ankara 有权
标题翻译: 基因间区域作为在修饰的痘苗病毒安卡拉基因组中插入HIV DNA序列的新位点公开(公告)号:US20060188961A1
公开(公告)日:2006-08-24
申请号:US11355948
申请日:2006-02-17
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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8.Method for generating a stable recombinant modified vaccinia virus ankara (MVA) comprising human immunodeficiency virus (HIV) genes inserted into one or more intergenic regions (IGRs) 有权
标题翻译: 用于产生包含插入到一个或多个基因间区域(IGR)中的人免疫缺陷病毒(HIV)基因的稳定的重组修饰的痘苗病毒安卡拉(MVA)的方法,公开(公告)号:US08323661B2
公开(公告)日:2012-12-04
申请号:US13221108
申请日:2011-08-30
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: A61K39/12 , A61K39/21 , A61K39/275 , C12N15/00
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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9.Method for the production of human immunodeficiency virus (HIV) proteins utilizing modified vaccinia virus ankara (MVA) recombinants comprising HIV genes inserted into one or more intergenic regions (IGRs) 有权
标题翻译: 使用包含插入到一个或多个基因间区域(IGR)中的HIV基因的修饰的痘苗病毒安卡拉(MVA)重组体生产人类免疫缺陷病毒(HIV)蛋白质的方法,公开(公告)号:US08197822B2
公开(公告)日:2012-06-12
申请号:US13209539
申请日:2011-08-15
申请人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul Howley , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: A61K39/12 , A61K39/21 , A61K39/275 , C12P21/06 , C12N15/00
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
摘要翻译: 本发明涉及可用于将HIV DNA序列整合到MVA基因组中的新插入位点以及所得重组MVA衍生物。
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公开(公告)号:US20120009214A1
公开(公告)日:2012-01-12
申请号:US13221952
申请日:2011-08-31
申请人: Paul HOWLEY , Sonja Leyrer , Paul Chaplin , Eva Felder
发明人: Paul HOWLEY , Sonja Leyrer , Paul Chaplin , Eva Felder
IPC分类号: A61K39/295 , A61P37/04 , A61P31/18 , C12N15/863
CPC分类号: C12N15/86 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/24122 , C12N2710/24143 , C12N2770/24122 , C12N2840/20 , C12N2840/203 , Y02A50/386 , Y02A50/39
摘要: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
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