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公开(公告)号：US09198886B2
公开(公告)日：2015-12-01
申请号：US12986674
申请日：2011-01-07
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Maria Luisa Krauel , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/185 , A61K31/192 , A61K31/235 , A61K31/56 , A61K45/06
CPC分类号： A61K31/185 , A61K31/192 , A61K31/235 , A61K31/56 , A61K45/06
摘要： The present invention relates to the use of a compound of Formula (IIV) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of macular degeneration, corneal neovascularization or angiogenesis, iris neovascularization or angiogenesis, retinal neovascularization or angiogenesis, diabetic proliferative retinopathy and non-diabetic proliferative retinopathy.
摘要翻译： 本发明涉及式（IIV）化合物或其药学上可接受的盐或溶剂化物，异构体或前体药物在制备用于治疗和/或预防任何选自下组的疾病的药物中的用途： 黄斑变性，角膜新生血管形成或血管生成，虹膜新生血管形成或血管生成，视网膜新生血管形成或血管生成，糖尿病性增生性视网膜病变和非糖尿病性增生性视网膜病变。
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公开(公告)号：US20120015912A1
公开(公告)日：2012-01-19
申请号：US12986674
申请日：2011-01-07
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Maria Luisa Krauel , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Maria Luisa Krauel , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A61K31/185 , C07C65/05 , A61K31/235 , A61K31/192 , A61K31/56 , A61P31/00 , A61P37/02 , A61P37/06 , A61P35/00 , A61P29/00 , A61P39/06 , A61P33/00 , A61P23/00 , A61P27/02 , C07C309/42
CPC分类号： A61K31/185 , A61K31/192 , A61K31/235 , A61K31/56 , A61K45/06
摘要： The present invention relates to the use of a compound of Formula (IIV) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of macular degeneration, corneal neovascularization or angiogenesis, iris neovascularization or angiogenesis, retinal neovascularization or angiogenesis, diabetic proliferative retinopathy and non-diabetic proliferative retinopathy.
摘要翻译： 本发明涉及式（IIV）化合物或其药学上可接受的盐或溶剂化物，异构体或前体药物在制备用于治疗和/或预防任何选自下组的疾病的药物中的用途： 黄斑变性，角膜新生血管形成或血管生成，虹膜新生血管形成或血管生成，视网膜新生血管形成或血管生成，糖尿病性增生性视网膜病变和非糖尿病性增生性视网膜病变。
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3.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ 有权2,5-二羟基苯化合物及其衍生物用于治疗器官的血液恶化和癌症公开(公告)号：US08541467B2
公开(公告)日：2013-09-24
申请号：US11839525
申请日：2007-08-15
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A01N37/02 , A01N41/10 , A01N31/08 , A61K31/22 , A61K31/225
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention refers to the use of the compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodisplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I″) for the treatment and/or prophylaxis of cancer of an organ.
摘要翻译： 本发明涉及式（I'）化合物或其药学上可接受的盐，溶剂合物，异构体或前体药物在治疗和/或预防血液恶化症中的用途，包括骨髓增生异常综合征（MDS）和用于改善功效 的化疗，放射治疗和/或癌症免疫治疗。 此外，它涉及式（I“）化合物用于治疗和/或预防器官癌症的用途。
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4.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US08101660B2
公开(公告)日：2012-01-24
申请号：US11839522
申请日：2007-08-15
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/222 , A61K31/12 , A61K31/10
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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5.发明申请USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF ROSACEA 有权使用2,5-二羟基苯乙烯化合物和衍生物用于治疗ROSACEA公开(公告)号：US20110237555A1
公开(公告)日：2011-09-29
申请号：US13154164
申请日：2011-06-06
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/60 , A61K31/222 , A61K31/255 , A61K31/225 , A61K31/192 , A61K31/56 , A61K31/4168 , A61P17/00 , A61P31/00 , A61P27/02
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药用于治疗和/或预防酒渣肠炎的用途。
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6.发明授权Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain 有权使用2,5-二羟基苯衍生物治疗关节炎和疼痛公开(公告)号：US09060966B2
公开(公告)日：2015-06-23
申请号：US12377837
申请日：2007-08-15
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez , Maria Luisa Krauel
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A61K31/045 , A61K31/15 , A61K31/10 , A61K31/192 , A61K31/60 , A61K31/618
CPC分类号： A61K31/10 , A61K31/192 , A61K31/60 , A61K31/618 , Y02A50/409
摘要： The present invention relates to the use of a compound of Formula (I′″) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of arthritis and pain.
摘要翻译： 本发明涉及式（I'“）化合物或其药学上可接受的盐或溶剂合物，异构体或前药在制备用于治疗和/或预防关节炎和疼痛的药物中的用途。
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7.发明申请Use of 2,5-Dihydroxybenzene Compounds and Derivatives for the Treatment of Psoriasis 审中-公开使用2,5-二羟基苯化合物和衍生物治疗牛皮癣公开(公告)号：US20080113948A1
公开(公告)日：2008-05-15
申请号：US11839520
申请日：2007-08-15
申请人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/60 , A61K31/59 , A61K31/56 , A61K31/185 , A61K31/22 , A61K31/225
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防银屑病方面的用途。
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8.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US08889737B2
公开(公告)日：2014-11-18
申请号：US13326778
申请日：2011-12-15
申请人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/222
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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9.发明申请Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US20120087904A1
公开(公告)日：2012-04-12
申请号：US13326778
申请日：2011-12-15
申请人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/60 , A61K31/185 , A61P35/00 , A61K31/437 , A61K31/196 , A61K38/46 , A61K31/513 , A61K31/202 , A61K31/675 , A61K31/22 , A61P31/00 , A61P25/04 , A61P37/02 , A61P23/00 , A61P29/00 , A61K31/19
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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10.发明申请Use of 2,5-Dihydroxybenzene Compounds and Derivatives for the Treatment of Hematological Dyscrasias and Cancer of an Organ 有权使用2,5-二羟基苯化合物和衍生物治疗血液性D摩擦症和器官癌公开(公告)号：US20080125486A1
公开(公告)日：2008-05-29
申请号：US11839525
申请日：2007-08-15
申请人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A61K31/22 , A61K31/192 , A61K31/185
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention refers to the use of the compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodisplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I″) for the treatment and/or prophylaxis of cancer of an organ.
摘要翻译： 本发明涉及式（I'）化合物或其药学上可接受的盐，溶剂合物，异构体或前体药物在治疗和/或预防血液恶化症中的用途，包括骨髓增生异常综合征（MDS）和用于改善功效 的化疗，放射治疗和/或癌症免疫治疗。 此外，它涉及式（I“）化合物用于治疗和/或预防器官癌症的用途。
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