公开(公告)号：US20240263132A1

公开(公告)日：2024-08-08

申请号：US18562387

申请日：2022-05-23

Applicant: Pfizer Inc.

Inventor： Robert George Konrad Donald ,  Aniruddha Sasmal

IPC: C12N1/20 ,  C07K14/26 ,  C12N9/10 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70 ,  C12R1/19

CPC classification number: C12N1/205 ,  C07K14/26 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70 ,  C12R2001/19 ,  C12Y504/99009

Abstract: This invention provides a recombinant Escherichia coli (E. coli) host cell for producing a Klebsiella pneumoniae (K. pneumoniae) O-antigen, wherein the E. coli host cell comprises a polynucleotide encoding the K. pneumoniae O-antigen, including methods of producing and purifying the K. pneumoniae O-antigen.