公开(公告)号：US10254286B2

公开(公告)日：2019-04-09

申请号：US14374083

申请日：2013-01-22

Applicant: Pfizer Inc. ,  Epic Sciences, Inc.

Inventor： Steven Pirie-Shepherd ,  Hans-Peter Gerber ,  Dena Marrinucci ,  Eric Tucker

IPC: G01N33/574 ,  G01N33/50

Abstract: Methods are provided for detecting 5T4-positive circulating tumor cells in a mammalian subject. Methods of diagnosing 5T4-positive cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of 5T4-positive metastatic cancer or early stage 5T4-positive cancer.

公开(公告)号：US11833216B2

公开(公告)日：2023-12-05

申请号：US18166774

申请日：2023-02-09

Applicant: Pfizer Inc.

Inventor： Andrea Therese Hooper ,  Kimberly Ann Marquette ,  Chakrapani Subramanyam ,  Hans-Peter Gerber ,  Chad Michael May

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08

CPC classification number: A61K47/6803 ,  A61K47/6843 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08 ,  A61K47/6811 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

公开(公告)号：US20150017661A1

公开(公告)日：2015-01-15

申请号：US14374083

申请日：2013-01-22

Applicant: Pfizer Inc. ,  Epic Sciences, Inc.

Inventor： Steven Pirie-Shepherd ,  Hans-Peter Gerber ,  Dena Marrinucci ,  Eric Tucker

IPC: G01N33/574

CPC classification number: G01N33/57492 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/57484 ,  G01N2333/70589

Abstract: Methods are provided for detecting 5T4-positive circulating tumor cells in a mammalian subject. Methods of diagnosing 5T4-positive cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of 5T4-positive metastatic cancer or early stage 5T4-positive cancer.

Abstract translation: 提供了用于检测哺乳动物受试者中5T4阳性循环肿瘤细胞的方法。 提供了在哺乳动物受试者中诊断5T4阳性癌症的方法。 检测或诊断的方法表明存在5T4阳性转移性癌症或早期5T4阳性癌症。