公开(公告)号：US20180155452A1

公开(公告)日：2018-06-07

申请号：US15840019

申请日：2017-12-13

Applicant: Pfizer Inc.

Inventor： Chad Michael May ,  Adam Reid Root ,  William A. Brady ,  Lioudmila Gennadievna Tchistiakova ,  Lidia Mosyak ,  Laird Bloom ,  Paul A. Moore ,  Leslie S. Johnson

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

公开(公告)号：US11833216B2

公开(公告)日：2023-12-05

申请号：US18166774

申请日：2023-02-09

Applicant: Pfizer Inc.

Inventor： Andrea Therese Hooper ,  Kimberly Ann Marquette ,  Chakrapani Subramanyam ,  Hans-Peter Gerber ,  Chad Michael May

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08

CPC classification number: A61K47/6803 ,  A61K47/6843 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08 ,  A61K47/6811 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

公开(公告)号：US09884921B2

公开(公告)日：2018-02-06

申请号：US14751704

申请日：2015-06-26

Applicant: Pfizer Inc.

Inventor： Chad Michael May ,  Adam Reid Root ,  William A. Brady ,  Lioudmila Gennadievna Tchistiakova ,  Lidia Mosyak ,  Laird Bloom ,  Paul A. Moore ,  Leslie S. Johnson

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.