公开(公告)号：US11840572B2

公开(公告)日：2023-12-12

申请号：US17378377

申请日：2021-07-16

Applicant: PFIZER INC.

Inventor： James Reasoner Apgar ,  Andrea Therese Hooper ,  Malgorzata Agnieszka Nocula-Lugowska ,  Lei Wu

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/2827 ,  A61P35/00 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 and CD3 (Cluster of Differentiation 3), and polynucleotides, pharmaceutical compositions and methods and uses thereof.

公开(公告)号：US20240018244A1

公开(公告)日：2024-01-18

申请号：US18449867

申请日：2023-08-15

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Andrea Therese Hooper ,  Malgorzata Agnieszka Nocula-Lugowska ,  Lei Wu

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2827 ,  A61P35/00 ,  C07K16/2809 ,  A61K2039/505

Abstract: The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 and CD3 (Cluster of Differentiation 3), and polynucleotides, pharmaceutical compositions and methods and uses thereof.

公开(公告)号：US11833216B2

公开(公告)日：2023-12-05

申请号：US18166774

申请日：2023-02-09

Applicant: Pfizer Inc.

Inventor： Andrea Therese Hooper ,  Kimberly Ann Marquette ,  Chakrapani Subramanyam ,  Hans-Peter Gerber ,  Chad Michael May

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08

CPC classification number: A61K47/6803 ,  A61K47/6843 ,  A61P35/00 ,  C07K16/18 ,  A61K38/08 ,  A61K47/6811 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.