公开(公告)号：US11434292B2

公开(公告)日：2022-09-06

申请号：US16417859

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Fang Jin ,  Madan Katragadda ,  Divya Mathur ,  Lioudmila Gennadievna Tchistiakova

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

Abstract: The present invention provides novel antibodies that specifically bind to CD3 and uses thereof. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

公开(公告)号：US20190382486A1

公开(公告)日：2019-12-19

申请号：US16417859

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： James Reasoner Apgar ,  Fang Jin ,  Madan Katragadda ,  Divya Mathur ,  Lioudmila Gennadievna Tchistiakova

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/30 ,  C07K16/40 ,  A61P35/00

Abstract: The present invention provides novel antibodies that specifically bind to CD3 and uses thereof. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

公开(公告)号：US11613581B2

公开(公告)日：2023-03-28

申请号：US16758124

申请日：2018-10-16

Applicant: Pfizer Inc.

Inventor： Manoj Baburao Charati ,  Yoon-Chi Han ,  Madan Katragadda ,  Nicole Melissa Piché-Nicholas ,  Lawrence Nathan Tumey

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C12N15/63 ,  A61K39/00

Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).

公开(公告)号：US11364303B2

公开(公告)日：2022-06-21

申请号：US16140115

申请日：2018-09-24

Applicant: PFIZER INC.

Inventor： Madan Katragadda ,  Russell Dushin ,  Lawrence Nathan Tumey

IPC: A61K47/68 ,  A61K47/54 ,  A61P31/00 ,  C07K16/32 ,  A61P35/00 ,  A61P37/06 ,  C07K16/28 ,  A61K39/00

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise an engineered cysteine for site-specific conjugation.

公开(公告)号：US11525010B2

公开(公告)日：2022-12-13

申请号：US16417863

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： Chew Shun Chang ,  Gurkan Guntas ,  Madan Katragadda ,  Divya Mathur ,  Adam Reid Root ,  Lidia Mosyak ,  Edward Roland LaVallie

IPC: C07K16/40 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

公开(公告)号：US20200010566A1

公开(公告)日：2020-01-09

申请号：US16417863

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： Chew Shun Chang ,  Gurkan Guntas ,  Madan Katragadda ,  Divya Mathur ,  Adam Reid Root ,  Lidia Mosyak ,  Edward Roland LaVallie

IPC: C07K16/40 ,  A61P35/00

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

公开(公告)号：US20190099499A1

公开(公告)日：2019-04-04

申请号：US16140115

申请日：2018-09-24

Applicant: PFIZER INC.

Inventor： Madan Katragadda ,  Russell Dushin ,  Lawrence Nathan Tumey

IPC: A61K47/68 ,  A61K47/54 ,  C07K16/32 ,  A61P35/00 ,  A61P37/06 ,  A61P31/00

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise an engineered cysteine for site-specific conjugation.