公开(公告)号：US11993625B2

公开(公告)日：2024-05-28

申请号：US16477290

申请日：2018-01-10

Applicant: PFIZER INC.

Inventor： Omar Khaled Ahmad ,  Stephen Paul Brown ,  Kenneth John Dirico ,  Russell Dushin ,  Gary Frederick Filzen ,  Sujiet Puthenveetil ,  Pavel Strop ,  Chakrapani Subramanyam ,  Lawrence N. Tumey

IPC: C07H15/26 ,  A61K47/68 ,  A61P35/00 ,  A61K45/06

CPC classification number: C07H15/26 ,  A61K47/6807 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

公开(公告)号：US20240409573A1

公开(公告)日：2024-12-12

申请号：US18627949

申请日：2024-04-05

Applicant: PFIZER INC.

Inventor： Omar Khaled Ahmad ,  Stephen Paul Brown ,  Kenneth John Dirico ,  Russell Dushin ,  Gary Frederick Filzen ,  Sujiet Puthenveetil ,  Pavel Strop ,  Chakrapani Subramanyam ,  Lawrence N. Tumey

IPC: C07H15/26 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

公开(公告)号：US11364303B2

公开(公告)日：2022-06-21

申请号：US16140115

申请日：2018-09-24

Applicant: PFIZER INC.

Inventor： Madan Katragadda ,  Russell Dushin ,  Lawrence Nathan Tumey

IPC: A61K47/68 ,  A61K47/54 ,  A61P31/00 ,  C07K16/32 ,  A61P35/00 ,  A61P37/06 ,  C07K16/28 ,  A61K39/00

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise an engineered cysteine for site-specific conjugation.

公开(公告)号：US10941216B2

公开(公告)日：2021-03-09

申请号：US15593259

申请日：2017-05-11

Applicant: PFIZER INC. ,  RINAT NEUROSCIENCE CORP.

Inventor： Pavel Strop ,  Magdalena Grazyna Dorywalska ,  Arvind Rajpal ,  David Shelton ,  Shu-Hui Liu ,  Jaume Pons ,  Russell Dushin

IPC: A61K47/68 ,  C07K16/00 ,  C07K17/02 ,  A61P43/00 ,  C07K16/30

Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

公开(公告)号：US20190099499A1

公开(公告)日：2019-04-04

申请号：US16140115

申请日：2018-09-24

Applicant: PFIZER INC.

Inventor： Madan Katragadda ,  Russell Dushin ,  Lawrence Nathan Tumey

IPC: A61K47/68 ,  A61K47/54 ,  C07K16/32 ,  A61P35/00 ,  A61P37/06 ,  A61P31/00

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise an engineered cysteine for site-specific conjugation.