公开(公告)号：US11746154B2

公开(公告)日：2023-09-05

申请号：US17450283

申请日：2021-10-07

Applicant: Pfizer Inc. ,  Children's Medical Center Corporation

Inventor： Florian Winau ,  Oleg V. Kovalenko ,  Chew Shun Chang ,  Di Wu ,  Nicholas Andrew Marze ,  Shian-Huey Chiang

IPC: A61K39/00 ,  A61K39/395 ,  C12N5/02 ,  C12N5/20 ,  C12N15/00 ,  C07K16/00 ,  C07K16/46 ,  C07H21/04 ,  C07K16/28 ,  A61P17/00

CPC classification number: C07K16/2833 ,  A61P17/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/92

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US11525010B2

公开(公告)日：2022-12-13

申请号：US16417863

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： Chew Shun Chang ,  Gurkan Guntas ,  Madan Katragadda ,  Divya Mathur ,  Adam Reid Root ,  Lidia Mosyak ,  Edward Roland LaVallie

IPC: C07K16/40 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

公开(公告)号：US20200010566A1

公开(公告)日：2020-01-09

申请号：US16417863

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： Chew Shun Chang ,  Gurkan Guntas ,  Madan Katragadda ,  Divya Mathur ,  Adam Reid Root ,  Lidia Mosyak ,  Edward Roland LaVallie

IPC: C07K16/40 ,  A61P35/00

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.