公开(公告)号：US20180155452A1

公开(公告)日：2018-06-07

申请号：US15840019

申请日：2017-12-13

Applicant: Pfizer Inc.

Inventor： Chad Michael May ,  Adam Reid Root ,  William A. Brady ,  Lioudmila Gennadievna Tchistiakova ,  Lidia Mosyak ,  Laird Bloom ,  Paul A. Moore ,  Leslie S. Johnson

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

公开(公告)号：US11525010B2

公开(公告)日：2022-12-13

申请号：US16417863

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： Chew Shun Chang ,  Gurkan Guntas ,  Madan Katragadda ,  Divya Mathur ,  Adam Reid Root ,  Lidia Mosyak ,  Edward Roland LaVallie

IPC: C07K16/40 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

公开(公告)号：US20200010566A1

公开(公告)日：2020-01-09

申请号：US16417863

申请日：2019-05-21

Applicant: Pfizer Inc.

Inventor： Chew Shun Chang ,  Gurkan Guntas ,  Madan Katragadda ,  Divya Mathur ,  Adam Reid Root ,  Lidia Mosyak ,  Edward Roland LaVallie

IPC: C07K16/40 ,  A61P35/00

Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel bispecific antibodies comprising such antibodies and uses thereof in the treatment of cancer.

公开(公告)号：US09884921B2

公开(公告)日：2018-02-06

申请号：US14751704

申请日：2015-06-26

Applicant: Pfizer Inc.

Inventor： Chad Michael May ,  Adam Reid Root ,  William A. Brady ,  Lioudmila Gennadievna Tchistiakova ,  Lidia Mosyak ,  Laird Bloom ,  Paul A. Moore ,  Leslie S. Johnson

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.