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Patent Agency Ranking
公开(公告)号：US11578428B2
公开(公告)日：2023-02-14
申请号：US16836986
申请日：2020-04-01
Applicant: Pfizer Inc.
Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.
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公开(公告)号：US20210040182A1
公开(公告)日：2021-02-11
申请号：US16836986
申请日：2020-04-01
Applicant: Pfizer Inc.
Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.
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公开(公告)号：US10647756B2
公开(公告)日：2020-05-12
申请号：US15155324
申请日：2016-05-16
Applicant: Pfizer Inc.
Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.
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公开(公告)号：US20160207991A1
公开(公告)日：2016-07-21
申请号：US14842422
申请日：2015-09-01
Applicant: Pfizer Inc.
Inventor： Laird Bloom , Qingcong Lin , Heather Hongrong Shih , Ying Sun , Orla Margaret Cunningham , William James Jonathan Finlay
IPC: C07K16/22 , A61K45/06 , A61K39/395 , A61K47/48 , A61K51/10
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: The present invention relates to antibodies that bind brain-derived neurotrophic factor (BDNF). The invention further relates to nucleic acid sequences coding for such antibodies. The present invention also relates to immunoconjugates comprising the antibodies of the invention and pharmaceutical compositions comprising the antibodies and/or the immunoconjugates. The present invention further relates to methods for treating pain and medical uses relating thereto.
Abstract translation: 本发明涉及结合脑源性神经营养因子（BDNF）的抗体。 本发明还涉及编码这种抗体的核酸序列。 本发明还涉及包含本发明抗体和包含抗体和/或免疫缀合物的药物组合物的免疫缀合物。 本发明还涉及治疗与其有关的疼痛和医疗用途的方法。
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公开(公告)号：US20170073395A1
公开(公告)日：2017-03-16
申请号：US15155324
申请日：2016-05-16
Applicant: Pfizer Inc.
CPC classification number: C07K16/00 , C07K16/18 , C07K16/40 , C07K16/464 , C07K2317/24 , C07K2317/565 , C07K2317/92 , C07K2317/94
Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.
Abstract translation: 本文公开了人源化抗体，其中人种系残基引入非人供体抗体的互补决定区（CDR）。 本文还描述了抗体可变结构域（例如，噬菌体展示文库）的文库和用于筛选人源化抗体的方法。
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