公开(公告)号：US20180155452A1

公开(公告)日：2018-06-07

申请号：US15840019

申请日：2017-12-13

Applicant: Pfizer Inc.

Inventor： Chad Michael May ,  Adam Reid Root ,  William A. Brady ,  Lioudmila Gennadievna Tchistiakova ,  Lidia Mosyak ,  Laird Bloom ,  Paul A. Moore ,  Leslie S. Johnson

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

公开(公告)号：US20160207991A1

公开(公告)日：2016-07-21

申请号：US14842422

申请日：2015-09-01

Applicant: Pfizer Inc.

Inventor： Laird Bloom ,  Qingcong Lin ,  Heather Hongrong Shih ,  Ying Sun ,  Orla Margaret Cunningham ,  William James Jonathan Finlay

IPC: C07K16/22 ,  A61K45/06 ,  A61K39/395 ,  A61K47/48 ,  A61K51/10

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K51/1021 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: The present invention relates to antibodies that bind brain-derived neurotrophic factor (BDNF). The invention further relates to nucleic acid sequences coding for such antibodies. The present invention also relates to immunoconjugates comprising the antibodies of the invention and pharmaceutical compositions comprising the antibodies and/or the immunoconjugates. The present invention further relates to methods for treating pain and medical uses relating thereto.

Abstract translation: 本发明涉及结合脑源性神经营养因子（BDNF）的抗体。 本发明还涉及编码这种抗体的核酸序列。 本发明还涉及包含本发明抗体和包含抗体和/或免疫缀合物的药物组合物的免疫缀合物。 本发明还涉及治疗与其有关的疼痛和医疗用途的方法。

公开(公告)号：US09884921B2

公开(公告)日：2018-02-06

申请号：US14751704

申请日：2015-06-26

Applicant: Pfizer Inc.

Inventor： Chad Michael May ,  Adam Reid Root ,  William A. Brady ,  Lioudmila Gennadievna Tchistiakova ,  Lidia Mosyak ,  Laird Bloom ,  Paul A. Moore ,  Leslie S. Johnson

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/626 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

公开(公告)号：US10544212B2

公开(公告)日：2020-01-28

申请号：US15495172

申请日：2017-04-24

Applicant: Pfizer Inc.

Inventor： Laird Bloom ,  Karl Henry Nocka ,  James Reasoner Apgar ,  Matthew Allister Lambert ,  Mark A. Farmer

IPC: C07K16/24 ,  A61K39/395 ,  A61K39/00

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.