公开(公告)号：US20200157212A1

公开(公告)日：2020-05-21

申请号：US16614701

申请日：2018-06-08

Applicant: Pfizer Inc. ,  Boston Medical Center Corporation

Inventor： Stephen Berasi ,  Janet Elizabeth Buhlmann ,  Eric M. Bennett ,  Nathan Higginson-Scott ,  Huilan Gao ,  Zong Sean Juo ,  Stefano V. Gulla ,  Christine Huard ,  Sreekumar R. Kodangattil ,  Jian Li ,  Weining Lu ,  Xueping Fan ,  David J. Salant

IPC: C07K16/28 ,  A61P13/12 ,  C12N15/85

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.

公开(公告)号：US20180179285A1

公开(公告)日：2018-06-28

申请号：US15309879

申请日：2015-05-13

Applicant: Pfizer Inc.

Inventor： Eric M. Bennett ,  Nathan Higginson-Scott ,  Lioudmila Tchistiakova ,  Kimberly A. Marquette ,  Janet E. Paulsen ,  Ruth E. Gimeno

IPC: C07K16/28 ,  A61P27/16 ,  C07K16/24

CPC classification number: C07K16/2863 ,  A61P27/16 ,  C07K16/00 ,  C07K16/24 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/75 ,  C07K2317/92

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.

公开(公告)号：US20240174742A1

公开(公告)日：2024-05-30

申请号：US18511744

申请日：2023-11-16

Applicant: PFIZER INC. ,  The Brigham and Women's Hospital, Inc.

Inventor： Stefano V. Gulla ,  Christine Huard ,  Janet Elizabeth Buhlmann ,  Juan Carlos Almagro ,  Sreekumar R. Kodangattil ,  Steven A. Greenberg ,  Edward Roland Lavallie ,  Eric M. Bennett ,  Lidia Mosyak ,  James Perry Hall ,  Anthony John Coyle

IPC: C07K16/24 ,  A61K39/00

CPC classification number: C07K16/249 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are are useful for various therapeutic or diagnostic purposes.

公开(公告)号：US20170073395A1

公开(公告)日：2017-03-16

申请号：US15155324

申请日：2016-05-16

Applicant: Pfizer Inc.

Inventor： William James Jonathan Finlay ,  Lioudmila Tchistiakova ,  Eric M. Bennett

IPC: C07K16/00 ,  C07K16/40 ,  C07K16/18

CPC classification number: C07K16/00 ,  C07K16/18 ,  C07K16/40 ,  C07K16/464 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94

Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.

Abstract translation: 本文公开了人源化抗体，其中人种系残基引入非人供体抗体的互补决定区（CDR）。 本文还描述了抗体可变结构域（例如，噬菌体展示文库）的文库和用于筛选人源化抗体的方法。

公开(公告)号：US20210163588A1

公开(公告)日：2021-06-03

申请号：US17092998

申请日：2020-11-09

Applicant: PFIZER INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Stefano V. Gulla ,  Christine Huard ,  Janet Elizabeth Buhlmann ,  Juan Carlos Almagro ,  Sreekumar R. Kodangattil ,  Steven A. Greenberg ,  Edward Roland Lavallie ,  Eric M. Bennett ,  Lidia Mosyak ,  James Perry Hall ,  Anthony John Coyle

IPC: C07K16/24

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are are useful for various therapeutic or diagnostic purposes.

公开(公告)号：US20210040182A1

公开(公告)日：2021-02-11

申请号：US16836986

申请日：2020-04-01

Applicant: Pfizer Inc.

Inventor： William James Jonathan Finlay ,  Lioudmila Tchistiakova ,  Eric M. Bennett

IPC: C07K16/00 ,  C07K16/18 ,  C07K16/40

Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.

公开(公告)号：US10392438B2

公开(公告)日：2019-08-27

申请号：US15309879

申请日：2015-05-13

Applicant: Pfizer Inc.

Inventor： Eric M. Bennett ,  Nathan Higginson-Scott ,  Lioudmila Tchistiakova ,  Kimberly A. Marquette ,  Janet E. Paulsen ,  Ruth E. Gimeno

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/24 ,  A61P27/16

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.

公开(公告)号：US11578428B2

公开(公告)日：2023-02-14

申请号：US16836986

申请日：2020-04-01

Applicant: Pfizer Inc.

Inventor： William James Jonathan Finlay ,  Lioudmila Tchistiakova ,  Eric M. Bennett

IPC: C40B50/06 ,  C07K16/00 ,  C07K16/18 ,  C07K16/40 ,  C40B40/10

Abstract: Disclosed herein are humanized antibodies in which human germline residues are introduces to the complementarity determining regions (CDRs) of a non-human donor antibody. Also described herein are libraries of antibody variable domains (e.g., phage-display libraries) and methods for screening for humanized antibodies.

公开(公告)号：US11365253B2

公开(公告)日：2022-06-21

申请号：US16614701

申请日：2018-06-08

Applicant: Pfizer Inc. ,  Boston Medical Center Corporation

Inventor： Stephen Berasi ,  Janet Elizabeth Buhlmann ,  Eric M. Bennett ,  Nathan Higginson-Scott ,  Huilan Gao ,  Zong Sean Juo ,  Stefano V. Gulla ,  Christine Huard ,  Sreekumar R. Kodangattil ,  Jian Li ,  Weining Lu ,  Xueping Fan ,  David J. Salant

IPC: C07H21/04 ,  C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N15/74 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  A61P13/12 ,  C12N15/85

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.

公开(公告)号：US10829553B2

公开(公告)日：2020-11-10

申请号：US15581079

申请日：2017-04-28

Applicant: PFIZER INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Stefano V. Gulla ,  Christine Huard ,  Janet Elizabeth Buhlmann ,  Juan Carlos Almagro ,  Sreekumar R. Kodangattil ,  Steven A. Greenberg ,  Edward Roland Lavallie ,  Eric M. Bennett ,  Lidia Mosyak ,  James Perry Hall ,  Anthony John Coyle

IPC: C07K16/24 ,  A61K39/00

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.