公开(公告)号：US20070142451A1

公开(公告)日：2007-06-21

申请号：US11548368

申请日：2006-10-11

申请人： Pingyun Chen ,  Qunying Dai ,  Philip Dell'Orco ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Clifford Labaw ,  Li-Jen Ping

发明人： Pingyun Chen ,  Qunying Dai ,  Philip Dell'Orco ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Clifford Labaw ,  Li-Jen Ping

IPC分类号： A61K31/403 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.

摘要翻译： 本发明涉及卡维地洛的盐，含有这种卡维地洛盐或其相应溶剂合物的相应组合物，和/或使用上述化合物治疗哺乳动物，特别是人中某些疾病状态的方法。 本发明还涉及1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] -2-丙醇的氢溴酸盐的新型结晶形式的卡维地洛氢溴酸盐，以及 /或其他卡维地洛溶剂化物，含有卡维地洛氢溴酸盐的盐或溶剂合物的组合物，以及使用上述化合物治疗高血压，充血性心力衰竭和心绞痛等的方法。

公开(公告)号：US20050277689A1

公开(公告)日：2005-12-15

申请号：US10997230

申请日：2004-11-24

申请人： Christopher Brook ,  Pingyun Chen ,  Wei Chen ,  Qunying Dai ,  Philip Dell'Orco ,  Clifford Labaw ,  Ann Diederich ,  Choon Oh ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Li-Jen Ping ,  Paul Spoors ,  Jun Wang ,  Christopher Werner

发明人： Christopher Brook ,  Pingyun Chen ,  Wei Chen ,  Qunying Dai ,  Philip Dell'Orco ,  Clifford Labaw ,  Ann Diederich ,  Choon Oh ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Li-Jen Ping ,  Paul Spoors ,  Jun Wang ,  Christopher Werner

IPC分类号： A61K31/403 ,  C07D209/82 ,  C07D209/88

CPC分类号： C07D209/88

摘要： The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛和/或其相应溶剂合物的盐，含有这种卡维地洛和/或其相应溶剂合物的组合物和/或使用上述化合物治疗哺乳动物某些疾病状态的方法， 特别的人 本发明还涉及卡维地洛磷酸盐和/或其溶剂合物，其包括新颖的卡维地洛磷酸二氢盐结晶形式（即它是1-（咔唑-4-基氧基-3 - [[2 - （邻甲氧基苯氧基）乙基]氨基] -2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其它相应的溶剂合物，含有这些卡维地洛磷酸盐和/或溶剂化物的组合物，以及使用上述 盐和/或溶剂化物治疗高血压，充血性心力衰竭和心绞痛等

公开(公告)号：US20050261355A1

公开(公告)日：2005-11-24

申请号：US10518206

申请日：2003-06-27

申请人： Pingyun Chen ,  Qunying Dai ,  Philip Cell'Orco ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Clifford Labaw ,  Li-Jen Ping

发明人： Pingyun Chen ,  Qunying Dai ,  Philip Cell'Orco ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Clifford Labaw ,  Li-Jen Ping

IPC分类号： A61K31/403 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D209/82 ,  C07D209/88

CPC分类号： C07D209/88

摘要： The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy)-3-[[2-(omethoxyphenoxyl)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.

摘要翻译： 本发明涉及卡维地洛的盐，含有这种卡维地洛盐或其相应溶剂合物的相应组合物，和/或使用上述化合物治疗哺乳动物，特别是人中某些疾病状态的方法。 本发明还涉及1-（咔唑-4-基氧基）-3 - [[2-（甲氧基苯氧基）乙基]氨基] -2-丙醇的氢溴酸盐和/ 或其它卡维地洛溶剂化物，含有盐酸卡维地洛氢溴酸盐或溶剂化物的组合物，以及使用上述化合物治疗高血压，充血性心力衰竭和心绞痛等的方法。

公开(公告)号：US20070244182A1

公开(公告)日：2007-10-18

申请号：US11767586

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

公开(公告)号：US20070238774A1

公开(公告)日：2007-10-11

申请号：US11767573

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

公开(公告)号：US20050240027A1

公开(公告)日：2005-10-27

申请号：US10518654

申请日：2003-06-27

申请人： Christopher Brook ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher Brook ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D209/82 ,  C07D209/88

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US20070259940A1

公开(公告)日：2007-11-08

申请号：US11767566

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/04 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate,etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂化物治疗高血压，充血性心力衰竭和 心绞痛等