公开(公告)号：US20070238774A1

公开(公告)日：2007-10-11

申请号：US11767573

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

公开(公告)号：US20050240027A1

公开(公告)日：2005-10-27

申请号：US10518654

申请日：2003-06-27

申请人： Christopher Brook ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher Brook ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D209/82 ,  C07D209/88

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US20080096951A1

公开(公告)日：2008-04-24

申请号：US11962163

申请日：2007-12-21

申请人： Wei CHEN ,  Choon Oh ,  Li-Jen Ping ,  Paul Spoors

发明人： Wei CHEN ,  Choon Oh ,  Li-Jen Ping ,  Paul Spoors

IPC分类号： A61K31/40 ,  A61P9/00 ,  C07D209/82

CPC分类号： C07D209/88 ,  A61K31/403

摘要： This invention relates to carvedilol monocitrate monohydrate, compositions containing this salt of carvedilol and methods of using this compound to treat hypertension, congestive heart failure and angina.

摘要翻译： 本发明涉及一水合卡维地洛，含有该卡那韦的盐的组合物和使用该化合物治疗高血压，充血性心力衰竭和心绞痛的方法。

公开(公告)号：US20070259940A1

公开(公告)日：2007-11-08

申请号：US11767566

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/04 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate,etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂化物治疗高血压，充血性心力衰竭和 心绞痛等

公开(公告)号：US20050277689A1

公开(公告)日：2005-12-15

申请号：US10997230

申请日：2004-11-24

申请人： Christopher Brook ,  Pingyun Chen ,  Wei Chen ,  Qunying Dai ,  Philip Dell'Orco ,  Clifford Labaw ,  Ann Diederich ,  Choon Oh ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Li-Jen Ping ,  Paul Spoors ,  Jun Wang ,  Christopher Werner

发明人： Christopher Brook ,  Pingyun Chen ,  Wei Chen ,  Qunying Dai ,  Philip Dell'Orco ,  Clifford Labaw ,  Ann Diederich ,  Choon Oh ,  Claire Hisler ,  David Igo ,  Lee Katrincic ,  Li-Jen Ping ,  Paul Spoors ,  Jun Wang ,  Christopher Werner

IPC分类号： A61K31/403 ,  C07D209/82 ,  C07D209/88

CPC分类号： C07D209/88

摘要： The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛和/或其相应溶剂合物的盐，含有这种卡维地洛和/或其相应溶剂合物的组合物和/或使用上述化合物治疗哺乳动物某些疾病状态的方法， 特别的人 本发明还涉及卡维地洛磷酸盐和/或其溶剂合物，其包括新颖的卡维地洛磷酸二氢盐结晶形式（即它是1-（咔唑-4-基氧基-3 - [[2 - （邻甲氧基苯氧基）乙基]氨基] -2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其它相应的溶剂合物，含有这些卡维地洛磷酸盐和/或溶剂化物的组合物，以及使用上述 盐和/或溶剂化物治疗高血压，充血性心力衰竭和心绞痛等

公开(公告)号：US20050148779A1

公开(公告)日：2005-07-07

申请号：US10512628

申请日：2003-04-30

申请人： Wei Chen ,  Choon Oh ,  Li-Jen Ping ,  Paul Spoors

发明人： Wei Chen ,  Choon Oh ,  Li-Jen Ping ,  Paul Spoors

IPC分类号： A61K31/403 ,  C07D209/88 ,  C07D209/82

CPC分类号： C07D209/88 ,  A61K31/403

摘要： This invention relates to carvedilol monocitrate monohydrate, compositions containing this salt of carvedilol and methods of using this compound to treat hypertension, congestive heart failure and angina.

摘要翻译： 本发明涉及一水合卡维地洛，含有该卡那韦的盐的组合物和使用该化合物治疗高血压，充血性心力衰竭和心绞痛的方法。

公开(公告)号：US20070244182A1

公开(公告)日：2007-10-18

申请号：US11767586

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'Orco ,  Lee Katrincic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

公开(公告)号：US20070244181A1

公开(公告)日：2007-10-18

申请号：US11767581

申请日：2007-06-25

申请人： Christopher BROOK ,  Wei Chen ,  Philip Dell'orco ,  Lee Katrinic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

发明人： Christopher BROOK ,  Wei Chen ,  Philip Dell'orco ,  Lee Katrinic ,  Ann Louvet ,  Choon Oh ,  Paul Spoors ,  Christopher Werner

IPC分类号： A61K31/403 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  C07D209/82

CPC分类号： C07D209/88

摘要： The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

摘要翻译： 本发明涉及卡维地洛磷酸盐，其包括新颖的卡维地洛磷酸二氢盐的结晶形式（即，1-（咔唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] - 2-丙醇）和/或卡维地洛磷酸氢盐等）和/或其溶剂合物，含有上述盐和/或溶剂合物的组合物，以及使用上述盐和/或溶剂合物治疗高血压，充血性心力衰竭和 心绞痛等