公开(公告)号：US20220214279A1

公开(公告)日：2022-07-07

申请号：US17704691

申请日：2022-03-25

Applicant: Quantum-Si Incorporated

Inventor： JONATHAN M. ROTHBERG ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Benjamin Ciperiany ,  Jack Jewell ,  Lawrence C. West ,  Michael Ferrigno ,  Paul E. Glenn ,  Adam Ezra Cohen ,  Anthony Bellofiore

IPC: G01N21/64 ,  B01L3/00 ,  G01N21/77 ,  C12Q1/6874 ,  C12Q1/6869

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.