公开(公告)号：US20200078475A1

公开(公告)日：2020-03-12

申请号：US16687789

申请日：2019-11-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Doron SHABAT ,  Rachel BLAU ,  Yana EPSHTEIN ,  Hemda BAABUR-COHEN ,  Shiran FERBER ,  Orit REDY-KEISAR ,  Einat KISIN-FINFER

IPC: A61K49/00 ,  A61K31/337 ,  A61K47/65 ,  A61K47/59 ,  A61K47/58

Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

公开(公告)号：US20170182176A1

公开(公告)日：2017-06-29

申请号：US15447257

申请日：2017-03-02

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Ela MARKOVSKY ,  Hemda BAABUR-COHEN

IPC: A61K47/48 ,  A61K31/704 ,  A61K31/337 ,  C08G69/08 ,  A61K9/51

CPC classification number: A61K47/48315 ,  A61K31/337 ,  A61K31/704 ,  A61K38/484 ,  A61K47/55 ,  A61K47/58 ,  A61K47/593 ,  A61K47/64 ,  A61K47/645 ,  A61K2300/00

Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.

公开(公告)号：US20170014531A1

公开(公告)日：2017-01-19

申请号：US15124360

申请日：2015-03-13

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Doron SHABAT ,  Rachel BLAU ,  Yana EPSHTEIN ,  Hemda BAABUR-COHEN ,  Shiran FERBER ,  Orit REDY-KEISAR ,  Einat KISIN-FINFER

IPC: A61K49/00 ,  A61K31/337 ,  A61K47/48

CPC classification number: A61K49/0054 ,  A61K31/337 ,  A61K47/58 ,  A61K47/593 ,  A61K47/65 ,  A61K49/0032

Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

Abstract translation: 公开了可用于有机应用的聚合体系。 聚合体系包含荧光或荧光部分和治疗活性剂，各自连接到相同或不同的聚合物部分。 聚合物体系被设计成使得响应于化学事件产生荧光信号，优选在接触在患病组织或器官中过度表达的分析物（例如酶）时产生荧光信号。 还公开了可用于包含在这种聚合物体系中的探针，制备这种探针的方法和聚合物体系，以及其在诊断和/或治疗应用中的用途。